Researchers have found that senescent cells express a senescence-associated glycoprotein (SAGP) localized to the lysosome, likely an attempted compensatory response to lysosomal stress characteristic of the senescent state. Distinctive features of senescent cells can be used to target them for destruction, thereby reducing the burden they place on aged tissues and achieving some degree of rejuvenation. In today’s research materials, researchers report on a demonstration to show that using SAGP as a target to clear senescent cells can reduce pathology in a mouse model of…
A Senolytic Vaccine Targeting SAGP Reduces Pathology in a Mouse Model of Alzheimer's Disease
Researchers have found that senescent cells express a senescence-associated glycoprotein (SAGP) localized to the lysosome, likely an attempted compensatory response to lysosomal stress characteristic of the senescent state. Distinctive features of senescent cells can be used to target them for destruction, thereby reducing the burden they place on aged tissues and achieving some degree of rejuvenation. In today’s research materials, researchers report on a demonstration to show that using SAGP as a target to clear senescent cells can reduce pathology in a mouse model of…