Age versus Frailty as a Predictor of Mortality

Source https://www.fightaging.org/archives/2021/10/age-versus-frailty-as-a-predictor-of-mortality/

A number of companies and research groups are performing drug discovery by using effects on frailty in mice as a readout. To what degree is frailty an adequate measure of the harms done by aging? One way to answer that question is to assess mortality in a human study population against a measure of frailty, with and without factoring in chronological age. Researchers here show that frailty is a fair marker for age-related mortality, but it is not a reflection of every degenerative, harmful process taking place under the hood. Frailty and age combined provide a better correlation with mortality than frailty alone, indicating that there are aspects of age-related decline that contribute meaningfully to mortality without producing evident frailty.

As populations get older, the association between chronological age and health status becomes increasingly heterogeneous. To describe this heterogen…

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