Axonal spheroids are a feature of neurodegenerative conditions, bubbles that form on axons and can contain entire cell organelles, in addition to molecular debris and other cell components. These spheroids are comparatively poorly understood, but are thought to be connected to the processes of autophagy and other modes of clearance of waste. Spheroids disrupt axonal function, and may rupture to spill their contents outside the cell, causing further issues. Today’s open access paper provides more evidence for the connection to portions of autophagy, specifically the formation of endolysosomes, when an endos…
Axonal Spheroids in Alzheimer's Disease, Connected to Amyloid and Autophagy
Axonal spheroids are a feature of neurodegenerative conditions, bubbles that form on axons and can contain entire cell organelles, in addition to molecular debris and other cell components. These spheroids are comparatively poorly understood, but are thought to be connected to the processes of autophagy and other modes of clearance of waste. Spheroids disrupt axonal function, and may rupture to spill their contents outside the cell, causing further issues. Today’s open access paper provides more evidence for the connection to portions of autophagy, specifically the formation of endolysosomes, when an endos…