Cancers Force T Cells into Senescence

Source https://www.fightaging.org/archives/2022/10/cancers-force-t-cells-into-senescence/

Established cancers aggressively manipulate the immune system to their advantage, co-opting innate and adaptive immune cells to support rather than attack a tumor. Researchers here note a mechanism by which cancerous tissue forces T cells into a senescent state. Inhibiting this transition makes the immune system more effective at attacking the cancer, where fired up by a suitable immunotherapy that overcomes other barriers that the cancer puts in place to suppress the immune response.

It is now recognized that T cell functional state in the <a href="https://en.wikipedia.org/wiki/Tumor_microenvi…

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