Delivery of TGF-β1 Following Heart Attack Reduces Reperfusion Injury

Source https://www.fightaging.org/archives/2024/04/delivery-of-tgf-%CE%B21-following-heart-attack-reduces-reperfusion-injury/

A heart attack is triggered by rupture of an atherosclerotic plaque and downstream blockage of an important vessel feeding oxygenated blood to heart tissue. Much of the permanent harm resulting from a heart attack occurs when blood flow is restored to ischemic tissue, however. A cascade of maladaptive reactions, inflammation, and cell death occurs, leading to scarring and loss of function in the heart muscle. This damage to the heart can be reduced to some degree by anti-inflammatory signaling applied soon after the heart attack takes place, as researchers here demonstrate.

Despite major improvements using primary percutaneous intervention (PPCI) to treat patients wi…

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