Does Amyloid-β Aggregation Cause Broad Disruption of Proteostasis?

Source https://www.fightaging.org/archives/2023/08/does-amyloid-%CE%B2-aggregation-cause-broad-disruption-of-proteostasis/

Researchers here speculate on the ability of insoluble amyloid-β aggregates to be broadly disruptive of the solubility of many other proteins, and thus disruptive to cell and tissue function. Is this important in aging? The evidence here shows the existence of the mechanism in a lower species, but that doesn’t necessarily show that it has a sizable effect in mammals. Still, it is an interesting concept, potentially linking everything we know about why amyloid-β increases with age to the observed general dysfunction of brain cells.

Loss of proteostasis is a highly conserved feature of aging across model organisms and typically results in the accumulation of insoluble protein aggregates. Protein insolubility is a central feature of m…

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