Enabling Microglia to Better Clear Amyloid by Interfering in the LILRB4-APOE Interaction

Source https://www.fightaging.org/archives/2024/04/enabling-microglia-to-better-clear-amyloid-by-interfering-in-the-lilrb4-apoe-interaction/

Researchers here describe a mechanism that reduces the ability of microglia to ingest and clear misfolded amyloid-β, the protein aggregates associated with Alzheimer’s disease. Interestingly, this involves APOE, and thus might be affected by the different APOE variants connected to Alzheimer’s disease risk. The researchers demonstrate that interfering in the interaction between APOE and the LILRB4 receptor present on microglia can restore microglia-mediated clearance of amyloid-β.

Tox…

Source https://www.fightaging.org/archives/2024/04/enabling-microglia-to-better-clear-amyloid-by-interfering-in-the-lilrb4-apoe-interaction/

Researchers here describe a mechanism that reduces the ability of microglia to ingest and clear misfolded amyloid-β, the protein aggregates associated with Alzheimer’s disease. Interestingly, this involves APOE, and thus might be affected by the different APOE variants connected to Alzheimer’s disease risk. The researchers demonstrate that interfering in the interaction between APOE and the LILRB4 receptor present on microglia can restore microglia-mediated clearance of amyloid-β.

Tox…

What Do You Think?

comments

Translate »