Follistatin Gene Therapy Doubles Muscle Mass in Mice

Source https://www.fightaging.org/archives/2020/05/follistatin-gene-therapy-doubles-muscle-mass-in-mice/

Follistatin is an inhibitor of myostatin. Blocking myostatin activity enhances muscle growth, with accompanying beneficial side-effects such as a loss of excess fat tissue. This is well proven. There are a good number of animal lineages (mice, dogs, cows, and so forth) resulting from natural or engineered myostatin loss of function mutations, and even a few well-muscled human individuals with similar mutations. A number of groups are at various stages in the development of therapies to either upregulate follistatin or inhibit myostatin. The latter is further along in the formal regulatory process: human trials have been conducted <a href="https://www.fightaging.org/archives/2015/12/results-from-…

Source https://www.fightaging.org/archives/2020/05/follistatin-gene-therapy-doubles-muscle-mass-in-mice/

Follistatin is an inhibitor of myostatin. Blocking myostatin activity enhances muscle growth, with accompanying beneficial side-effects such as a loss of excess fat tissue. This is well proven. There are a good number of animal lineages (mice, dogs, cows, and so forth) resulting from natural or engineered myostatin loss of function mutations, and even a few well-muscled human individuals with similar mutations. A number of groups are at various stages in the development of therapies to either upregulate follistatin or inhibit myostatin. The latter is further along in the formal regulatory process: human trials have been conducted <a href="https://www.fightaging.org/archives/2015/12/results-from-…

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