In recent years, researchers have identified a variant of the gene BPIFB4 that correlates with longevity in humans, and in mice appears to suppress mechanisms in immune cells that contribute to chronic inflammation. In this paper, researchers use gene therapy to deliver the longevity-associated variant of BPIFB4 to old mice, and find that it reduces the presence of inflammatory immune cells showing markers of cellular senescence. The chronic inflammation of aging is known to contribute to many different age-related conditions, and the growing presence of senescent …
Gene Therapy Delivering the Longevity-Associated Variant of BPIFB4 Improves Immune Function in Old Mice
In recent years, researchers have identified a variant of the gene BPIFB4 that correlates with longevity in humans, and in mice appears to suppress mechanisms in immune cells that contribute to chronic inflammation. In this paper, researchers use gene therapy to deliver the longevity-associated variant of BPIFB4 to old mice, and find that it reduces the presence of inflammatory immune cells showing markers of cellular senescence. The chronic inflammation of aging is known to contribute to many different age-related conditions, and the growing presence of senescent …