Tauopathies like Alzheimer’s disease are characterized by the spread of tau aggregates through the brain. Tau is one of the few molecules in the body that can become altered in a way that encourages other copies of the same molecule to also alter, causing aggregates to form. These aggregates and their surrounding biochemistry are disruptive to cell function and toxic to cells. A number of neurodegnerative conditions are associated with protein aggregates of amyloid-β, α-synuclein, and tau. The mechanisms by which this spread occurs are debated, but researchers <a href="https://www.fightaging.org/archives/2021/08/a-bidirectional-relationship-between-pathological-tau-aggregation-and-senescent-…
Glial Cells and the Propagation of Tau through the Brain in Tauopathies
Tauopathies like Alzheimer’s disease are characterized by the spread of tau aggregates through the brain. Tau is one of the few molecules in the body that can become altered in a way that encourages other copies of the same molecule to also alter, causing aggregates to form. These aggregates and their surrounding biochemistry are disruptive to cell function and toxic to cells. A number of neurodegnerative conditions are associated with protein aggregates of amyloid-β, α-synuclein, and tau. The mechanisms by which this spread occurs are debated, but researchers <a href="https://www.fightaging.org/archives/2021/08/a-bidirectional-relationship-between-pathological-tau-aggregation-and-senescent-…