HAND2 Overexpression in Sympathetic Neurons Slows the Onset of Sarcopenia in Aged Mice

Source https://www.fightaging.org/archives/2020/12/hand2-overexpression-in-sympathetic-neurons-slows-the-onset-of-sarcopenia-in-aged-mice/

Researchers here show that upregulation of HAND2 in sympathetic neurons has the effect of slowing sarcopenia in late life, the loss of muscle mass and strength that leads to frailty. One contributing cause of sarcopenia is the deterioration of the neuromuscular junctions that link the nervous system with muscle tissue. This approach slows that deterioration, with a corresponding slowing of loss of muscle function, and thus puts some numbers to the importance of that causes versus, say, loss of stem cell function.

Sarcopenia, or age-dependent decline in muscle force and power, impai…

Source https://www.fightaging.org/archives/2020/12/hand2-overexpression-in-sympathetic-neurons-slows-the-onset-of-sarcopenia-in-aged-mice/

Researchers here show that upregulation of HAND2 in sympathetic neurons has the effect of slowing sarcopenia in late life, the loss of muscle mass and strength that leads to frailty. One contributing cause of sarcopenia is the deterioration of the neuromuscular junctions that link the nervous system with muscle tissue. This approach slows that deterioration, with a corresponding slowing of loss of muscle function, and thus puts some numbers to the importance of that causes versus, say, loss of stem cell function.

Sarcopenia, or age-dependent decline in muscle force and power, impai…

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