Investigating the Mechanisms by which Klotho Increases Autophagy

Source https://www.fightaging.org/archives/2019/10/investigating-the-mechanisms-by-which-klotho-increases-autophagy/

Expression of the klotho gene declines with age, while approaches that increase levels of the klotho protein have been demonstrated to slow aging in mice. Some fraction of this outcome stems from increased activity of the cellular housekeeping processes of autophagy, responsible for recycling metabolic waste and damaged molecular machinery and cellular components. Many of the methods of modestly slowing aging in laboratory species are characterized by upregulated autophagy, and some, such as calorie restriction, require functional autophagy in order to slow aging.

In order to study autophagy, resear…

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