Klotho Promotes Autophagy to Slow Vascular Calcification

Source https://www.fightaging.org/archives/2022/11/klotho-promotes-autophagy-to-slow-vascular-calcification/

Klotho is one of the few robustly determined longevity genes capable of altering life span in both directions in mice. A reduced expression of klotho shortens life span, while increased klotho levels lengthen life. Klotho has been shown to improve cognitive function, but investigation to date has suggested that it primarily functions in the kidney, and that kidney function mediates effects elsewhere in the body.

Today’s open access paper is focused instead on the relationship between klotho and vascular ca…

Source https://www.fightaging.org/archives/2022/11/klotho-promotes-autophagy-to-slow-vascular-calcification/

Klotho is one of the few robustly determined longevity genes capable of altering life span in both directions in mice. A reduced expression of klotho shortens life span, while increased klotho levels lengthen life. Klotho has been shown to improve cognitive function, but investigation to date has suggested that it primarily functions in the kidney, and that kidney function mediates effects elsewhere in the body.

Today’s open access paper is focused instead on the relationship between klotho and vascular ca…

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