The balance of microbial populations making up the gut microbiome changes with age in ways that are damaging to long-term health. Firstly the proportion of pro-inflammatory microbes grows, provoking the immune system into greater degrees of unresolved inflammation. This state of inflammaging observed in older individuals is disruptive to tissue structure and function throughout the body, and contributes meaningfully to the onset and progression of many age-related conditions. Secondly, the proportion of microbes generating beneficial metabolites …
Loss of Anti-Microbial Peptides as a Mechanism for Age-Related Changes in Gut Microbiome Composition
The balance of microbial populations making up the gut microbiome changes with age in ways that are damaging to long-term health. Firstly the proportion of pro-inflammatory microbes grows, provoking the immune system into greater degrees of unresolved inflammation. This state of inflammaging observed in older individuals is disruptive to tissue structure and function throughout the body, and contributes meaningfully to the onset and progression of many age-related conditions. Secondly, the proportion of microbes generating beneficial metabolites …