The practice of calorie restriction is well documented to slow the progression of aging in mammals. In humans, there is comprehensive evidence for it to improve measures of health and reduce the risk of age-related disease. The mechanisms by which calorie restriction produces benefits are essentially the same across species, an upregulation of various stress response mechanisms that maintain and repair cell function. The short-term health benefits, the specific outcomes resulting from this favorable alteration in the operation of cellular metabolism, are also very similar. However, the extension of life span produced by calorie restriction diminishes as species life span increases. Calorie restriction can extend life in mice by up to 40%, but is thought to <a href="https://www.fightaging.org/archives/2005/08/michael-rose-on-calorie-restri…
Mechanisms by which Calorie Restriction Delays the Onset of Sarcopenia
The practice of calorie restriction is well documented to slow the progression of aging in mammals. In humans, there is comprehensive evidence for it to improve measures of health and reduce the risk of age-related disease. The mechanisms by which calorie restriction produces benefits are essentially the same across species, an upregulation of various stress response mechanisms that maintain and repair cell function. The short-term health benefits, the specific outcomes resulting from this favorable alteration in the operation of cellular metabolism, are also very similar. However, the extension of life span produced by calorie restriction diminishes as species life span increases. Calorie restriction can extend life in mice by up to 40%, but is thought to <a href="https://www.fightaging.org/archives/2005/08/michael-rose-on-calorie-restri…