Mitochondrial Protein Import Systems Influence Longevity

Source https://www.fightaging.org/archives/2022/02/mitochondrial-protein-import-systems-influence-longevity/

Mitochondria, the power plants of the cell, are the evolved descendants of ancient symbiotic bacteria. They have a small remnant mitochondrial genome, but over time most of the proteins necessary to mitochondrial function migrated to the nuclear genome. Such proteins are produced in the normal way in and around the cell nucleus, and are then imported into mitochondria for use. Researchers here investigate how this import system relates to longevity, finding that it can be adjusted in ways that influence quality control mechanisms and other aspects of mitochondrial metabolism.

Sustained mitochondrial fitness relies on coordinated <a href="https://en.wikipedia.org/wiki/…

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