MKP1 as a Target for Idiopathic Pulmonary Fibrosis

Source https://www.fightaging.org/archives/2024/04/mkp1-as-a-target-for-idiopathic-pulmonary-fibrosis/

The causes of idiopathic pulmonary fibrosis remain somewhat unclear, which is often the case for conditions in which treatments struggle to achieve more than a slowed progression. There is evidence for cellular senescence to drive the progression of fibrosis, but most research remains focused on the molecular biochemistry of fibroblasts, the cells responsible for building the collagen deposits characteristic of fibrotic tissue.

The process by which lung injury either leads to healing or fibrosis relies in part on what happens to a cell called a fibroblast, which forms connective tissue. Dur…

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