Source https://www.fightaging.org/archives/2022/03/partially-inhibiting-mitochondrial-complex-i-as-an-approach-to-therapy/
Manipulation of cellular biochemistry in order to provoke beneficial stress responses, in a similar way to the outcome of calorie restriction, heat and cold stress, oxidative stress, and so forth, is a popular area of development in aging research. It dovetails well with the established infrastructure for discovering and vetting small molecule drugs, and there are many potential points of intervention in signaling pathways in a cell. Unfortunately the effect sizes leave something to be desired; few pharmacological approaches to stress response upregulation come with evidence to suggest that they are an improvement over exercise or the practice of calorie restriction.
One of the better explored appro…
Source https://www.fightaging.org/archives/2022/03/partially-inhibiting-mitochondrial-complex-i-as-an-approach-to-therapy/
Manipulation of cellular biochemistry in order to provoke beneficial stress responses, in a similar way to the outcome of calorie restriction, heat and cold stress, oxidative stress, and so forth, is a popular area of development in aging research. It dovetails well with the established infrastructure for discovering and vetting small molecule drugs, and there are many potential points of intervention in signaling pathways in a cell. Unfortunately the effect sizes leave something to be desired; few pharmacological approaches to stress response upregulation come with evidence to suggest that they are an improvement over exercise or the practice of calorie restriction.
One of the better explored appro…
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