Source https://www.fightaging.org/archives/2021/08/procaine-as-an-example-of-the-slow-reclassification-of-known-small-molecule-drugs-as-geroprotectors/
The classification of “geroprotector” is fairly recent. In present use, it largely means a small molecule drug that can favorably target mechanisms known to be associated with aging. Some of these small molecules come with evidence for a slowing of aging in animal studies. A very few can boast evidence for the same from human trials. Most geroprotectors target stress response mechanisms, those involved in calorie restriction, but senotherapeutic drugs that reduce the burden of cellular senescence might also be classed as geroprotectors.
That a drug can be called geroprotective is no guarantee that it is actually useful, of course. Effect size…
Source https://www.fightaging.org/archives/2021/08/procaine-as-an-example-of-the-slow-reclassification-of-known-small-molecule-drugs-as-geroprotectors/
The classification of “geroprotector” is fairly recent. In present use, it largely means a small molecule drug that can favorably target mechanisms known to be associated with aging. Some of these small molecules come with evidence for a slowing of aging in animal studies. A very few can boast evidence for the same from human trials. Most geroprotectors target stress response mechanisms, those involved in calorie restriction, but senotherapeutic drugs that reduce the burden of cellular senescence might also be classed as geroprotectors.
That a drug can be called geroprotective is no guarantee that it is actually useful, of course. Effect size…
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