In today’s open access paper, the authors report on inroads in counting senescent immune cells in blood samples from human patients of different ages. Accurate determination of senescence status isn’t cut and dried for many types of immune cell, but the researchers believe they have produced good numbers for cytotoxic T cells, showing that older people have many more senescent cells in this category. I’d like to see more of this sort of research, establishing some sort of baseline of expectations for levels of cellular senescence in various tissues by age, leading towards assays that can be used to directly the measure the outcome of treatment with senolytic drugs to selectively destroy se…
Putting Some Numbers to Senescent Immune Cell Counts in Humans by Age
In today’s open access paper, the authors report on inroads in counting senescent immune cells in blood samples from human patients of different ages. Accurate determination of senescence status isn’t cut and dried for many types of immune cell, but the researchers believe they have produced good numbers for cytotoxic T cells, showing that older people have many more senescent cells in this category. I’d like to see more of this sort of research, establishing some sort of baseline of expectations for levels of cellular senescence in various tissues by age, leading towards assays that can be used to directly the measure the outcome of treatment with senolytic drugs to selectively destroy se…