SIRT3 beneficially affects mitochondrial function, and its upregulation is a calorie restriction mimetic strategy, since it mediates some of the benefits resulting from a lowered calorie intake. Given this, there is some interest in this as a basis for treatments for neurodegenerative conditions, in which loss of mitochondrial function in the brain is thought to be an important contribution to pathology. Mitochondria are the power plants of the cell, and the brain requires a great deal of energy to operate. So far, efforts to improve mitochondrial function in aged tissues by targeting the expressed levels of specific proteins or <a href="https://en.wikipedia.org/wiki/Metabolite…
SIRT3 Upregulation as a Basis for Improving Mitochondrial Function in the Aging Brain
SIRT3 beneficially affects mitochondrial function, and its upregulation is a calorie restriction mimetic strategy, since it mediates some of the benefits resulting from a lowered calorie intake. Given this, there is some interest in this as a basis for treatments for neurodegenerative conditions, in which loss of mitochondrial function in the brain is thought to be an important contribution to pathology. Mitochondria are the power plants of the cell, and the brain requires a great deal of energy to operate. So far, efforts to improve mitochondrial function in aged tissues by targeting the expressed levels of specific proteins or <a href="https://en.wikipedia.org/wiki/Metabolite…