Source https://www.fightaging.org/archives/2022/04/supporting-evidence-for-somatic-mutations-to-be-an-important-contributing-cause-of-aging/
In today’s open access paper, researchers presented data on the pace at which random mutational damage accumulates in the nuclear DNA of somatic cells over a lifetime, covering a range of mammalian species with differing body sizes and life spans. They looked only at the lining of the gut, a tissue in which cells replicate rapidly, and thus one might expect to find more mutations and thus data that is more easily analyzed. The researchers found that the burden of mutations in late life is remarkably consistent, the rate of mutation inversely correlated with species life span. This is suggestive that somatic mutations are either an important contributing cause of aging, or a side-effect that is strongly connected to an important contributing cause of aging.
How could random mutational damage in cells throughout the body contribute to aging? Most of that dam…
Source https://www.fightaging.org/archives/2022/04/supporting-evidence-for-somatic-mutations-to-be-an-important-contributing-cause-of-aging/
In today’s open access paper, researchers presented data on the pace at which random mutational damage accumulates in the nuclear DNA of somatic cells over a lifetime, covering a range of mammalian species with differing body sizes and life spans. They looked only at the lining of the gut, a tissue in which cells replicate rapidly, and thus one might expect to find more mutations and thus data that is more easily analyzed. The researchers found that the burden of mutations in late life is remarkably consistent, the rate of mutation inversely correlated with species life span. This is suggestive that somatic mutations are either an important contributing cause of aging, or a side-effect that is strongly connected to an important contributing cause of aging.
How could random mutational damage in cells throughout the body contribute to aging? Most of that dam…
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