The Dog Aging Project Forges Ahead with a Large Study

Source https://www.fightaging.org/archives/2019/11/the-dog-aging-project-forges-ahead-with-a-large-study/

As noted here by the Life Extension Advocacy Foundation, the Dog Aging Project researchers are moving ahead with a large study of companion animals. While much of the study is observational, a sizable cohort will be treated with the mTOR inhibitor rapamycin. Dogs are much closer to humans than mice, so it will be interesting to see what results. Given what is known of the way in which stress response upregulation behaves in different species, we would expect to see similar effects on cellular biochemistry – such as upregulation of autophagy – but smaller relative gains in life span in dogs versus mice. Short-lived species have a much greater plasticity of life span in response…

Source https://www.fightaging.org/archives/2019/11/the-dog-aging-project-forges-ahead-with-a-large-study/

As noted here by the Life Extension Advocacy Foundation, the Dog Aging Project researchers are moving ahead with a large study of companion animals. While much of the study is observational, a sizable cohort will be treated with the mTOR inhibitor rapamycin. Dogs are much closer to humans than mice, so it will be interesting to see what results. Given what is known of the way in which stress response upregulation behaves in different species, we would expect to see similar effects on cellular biochemistry – such as upregulation of autophagy – but smaller relative gains in life span in dogs versus mice. Short-lived species have a much greater plasticity of life span in response…