The Many Roles of Senescent Cells

Source https://www.fightaging.org/archives/2019/10/the-many-roles-of-senescent-cells/

Long-lived senescent cells accumulate with age, initially quite slowly as they are efficiently removed by the immune system when their own programmed cell death processes fail, but once the immune system starts to decline with age, the burden of cellular senescence ramps up dramatically. Senescent cells secrete a potent mix of signals known as a senescence-associated secretory phenotype (SASP). It spurs chronic inflammation, destructively remodels nearby tissue, <a href="https://www.fightaging.org/archives/201…

Source https://www.fightaging.org/archives/2019/10/the-many-roles-of-senescent-cells/

Long-lived senescent cells accumulate with age, initially quite slowly as they are efficiently removed by the immune system when their own programmed cell death processes fail, but once the immune system starts to decline with age, the burden of cellular senescence ramps up dramatically. Senescent cells secrete a potent mix of signals known as a senescence-associated secretory phenotype (SASP). It spurs chronic inflammation, destructively remodels nearby tissue, <a href="https://www.fightaging.org/archives/201…