Towards Ways to Encourage Cells to Degrade Greater Amounts of Tau Protein

Source https://www.fightaging.org/archives/2023/01/towards-ways-to-encourage-cells-to-degrade-greater-amounts-of-tau-protein/

Researchers here report on an investigation of mechanisms regulating the turnover of tau protein in brain cells. The hope is to find approaches that will more aggressively clear the tau aggregates found in neurodegenerative conditions via the usual cell maintenance processes responsible for breaking down excess proteins, such as autophagy and proteasomal degradation. It is far too early to say how promising this approach might turn out to be at the end of the day, but the initial exploration is interesting.

A novel screening approach led researchers to 11 new in vivo validated tau regulators. Of these, three targets – ubiquitin-sp…