TREM2 Influences the Formation of Unstable Atherosclerotic Plaque

Source https://www.fightaging.org/archives/2024/03/trem2-influences-the-formation-of-unstable-atherosclerotic-plaque/

The growth of atherosclerotic plaques in blood vessels is harmful, not least because it restricts blood flow, even blocking entire vessels in the worst cases. The vast majority of cardiovascular mortality results from the rupture of fatty, unstable plaques, however, leading to stroke and heart attack when the fragments block downstream vessels. If the development of plaque instability could be slowed or reversed, this would have a sizable impact on cardiovascular mortality – even given that this goal is a step down from reversal of plaque in general. Thus researchers are interested in finding the mechanisms that determine whether a plaque is more fatty and less fibrous, and thus more prone to rupture.

Atherosclerosis is a c…

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