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A Few More Mammalian Species Found to Exhibit Amyloid-β and Tau Pathology

Source https://www.fightaging.org/archives/2021/01/a-few-more-mammalian-species-found-to-exhibit-amyloid-%CE%B2-and-tau-pathology/

The primary challenge in Alzheimer’s disease research has long been that short-lived laboratory species do not naturally exhibit any of the features of the condition. Thus all mouse models of the condition are highly artificial genetic constructs, and potential treatments and relevant mechanisms in these models have a high chance of being irrelevant to Alzheimer’s disease as it exists in humans. Up until fairly recently it could be argued that humans were in fact the only species to exhibit full blown Alzheimer’s disease, involving a lengthy increase in amyloid-β aggregation in the brain, followed by neuroinflammation, tau aggregation, and widespread cell death.

However, in…

Source https://www.fightaging.org/archives/2021/01/a-few-more-mammalian-species-found-to-exhibit-amyloid-%CE%B2-and-tau-pathology/

The primary challenge in Alzheimer’s disease research has long been that short-lived laboratory species do not naturally exhibit any of the features of the condition. Thus all mouse models of the condition are highly artificial genetic constructs, and potential treatments and relevant mechanisms in these models have a high chance of being irrelevant to Alzheimer’s disease as it exists in humans. Up until fairly recently it could be argued that humans were in fact the only species to exhibit full blown Alzheimer’s disease, involving a lengthy increase in amyloid-β aggregation in the brain, followed by neuroinflammation, tau aggregation, and widespread cell death.

However, in…

Xponential Fitness Promotes Pure Barre President Sarah Luna to New Xponential President Role

Source https://www.clubindustry.com/commercial-clubs/xponential-fitness-promotes-pure-barre-president-sarah-luna-to-new-xponential

Xponential Fitness Promotes Pure Barre President Sarah Luna to New Xponential President Role
pkufahl
Thu, 01/14/2021 – 08:47
<a class="a2a_button_print…

Source https://www.clubindustry.com/commercial-clubs/xponential-fitness-promotes-pure-barre-president-sarah-luna-to-new-xponential

Xponential Fitness Promotes Pure Barre President Sarah Luna to New Xponential President Role
pkufahl
Thu, 01/14/2021 – 08:47
<a class="a2a_button_print…

If You’re Insecure and Afraid of Rejection Like Me…

Source http://feedproxy.google.com/~r/tinybuddha/~3/1plXI7VvXf8/

“How brave the moon shines in her skin; outnumbered by the stars.” ~Angie Welland-Crosby

I have this reoccurring dream where I am about to teach a yoga class. I stand to teach, and no one is paying any attention to me. They are all distracted or in deep conversation with one another and have no interest in engaging in the class.

As I begin, one by one the students get up and leave. I am mortified and discouraged, though I continue to teach anyway.

I wake up from the dream with a sinking feeling in my stomach and heaviness in my heart. Rather than indulge and spiral into sadness, I turn directly toward the aching.

“Where is this coming from?” This is the question I ask myself as I dive into self-healing. Just as the body has the ability to heal itself on a…

Source http://feedproxy.google.com/~r/tinybuddha/~3/1plXI7VvXf8/

“How brave the moon shines in her skin; outnumbered by the stars.” ~Angie Welland-Crosby

I have this reoccurring dream where I am about to teach a yoga class. I stand to teach, and no one is paying any attention to me. They are all distracted or in deep conversation with one another and have no interest in engaging in the class.

As I begin, one by one the students get up and leave. I am mortified and discouraged, though I continue to teach anyway.

I wake up from the dream with a sinking feeling in my stomach and heaviness in my heart. Rather than indulge and spiral into sadness, I turn directly toward the aching.

“Where is this coming from?” This is the question I ask myself as I dive into self-healing. Just as the body has the ability to heal itself on a…

How to Let Go of the Need to Control People and Life

Source http://feedproxy.google.com/~r/tinybuddha/~3/nVs-_aOIE7U/

“Anything you can’t control is teaching you how to let go.” ~Jackson Kiddard

Fellow perfectionists, I’m guessing you know what it’s like: the constant need to control life and other people to ensure everything goes smoothly and everyone’s okay.

It’s a maddening, exhausting habit, since the only thing we can control is ourselves. But we do it anyways—because somewhere along the line we learned this was the only way to keep ourselves (and others) safe.

Maybe you try to control your work and your colleagues, because you think you have to in order to succeed and to ensure your coworkers do the same quality work, especially when it affects you.

Maybe you try to control your family, because you think you know what’s best for them and don’t tr…

Source http://feedproxy.google.com/~r/tinybuddha/~3/nVs-_aOIE7U/

“Anything you can’t control is teaching you how to let go.” ~Jackson Kiddard

Fellow perfectionists, I’m guessing you know what it’s like: the constant need to control life and other people to ensure everything goes smoothly and everyone’s okay.

It’s a maddening, exhausting habit, since the only thing we can control is ourselves. But we do it anyways—because somewhere along the line we learned this was the only way to keep ourselves (and others) safe.

Maybe you try to control your work and your colleagues, because you think you have to in order to succeed and to ensure your coworkers do the same quality work, especially when it affects you.

Maybe you try to control your family, because you think you know what’s best for them and don’t tr…

Why Judging People Is Really About You (Not Them)

Source http://feedproxy.google.com/~r/tinybuddha/~3/tdQILQVKOgw/

“It’s easy to judge. It’s more difficult to understand. Understanding requires compassion, patience, and a willingness to believe that good hearts sometimes choose poor methods. Through judging, we separate. Through understanding, we grow.” ~Doe Zantamata

Why doesn’t he say something?

I was sitting at the dinner table with my partner and friends. Everyone was interacting and talking to each other, except my partner. He was just sitting there quietly. I had to admit, this situation made me very uncomfortable.

Why was he so quiet? We had been dating for over six months and normally, when it was just the two of us, he was very talkative, we had vivid discussions, he knew his opinions and was not afraid to speak his mind. But now, at a dinner with frie…

Source http://feedproxy.google.com/~r/tinybuddha/~3/tdQILQVKOgw/

“It’s easy to judge. It’s more difficult to understand. Understanding requires compassion, patience, and a willingness to believe that good hearts sometimes choose poor methods. Through judging, we separate. Through understanding, we grow.” ~Doe Zantamata

Why doesn’t he say something?

I was sitting at the dinner table with my partner and friends. Everyone was interacting and talking to each other, except my partner. He was just sitting there quietly. I had to admit, this situation made me very uncomfortable.

Why was he so quiet? We had been dating for over six months and normally, when it was just the two of us, he was very talkative, we had vivid discussions, he knew his opinions and was not afraid to speak his mind. But now, at a dinner with frie…

What Happened When I Stopped Drinking Alcohol Every Night

Source http://feedproxy.google.com/~r/tinybuddha/~3/br57PgaLcfI/

“First you take a drink, then the drink takes a drink, then the drink takes you.” ~F. Scott Fitzgerald

I love Sophia Loren. There’s a picture of her in my home looking eternally youthful and refreshed. From what I’ve been told it’s due to her nine to ten hours of sleep each night.

When I look at this picture, I see someone who relishes in the delights of life. Food, laughter, sex, work, motherhood, and self-care. Not long ago I stared at that picture thinking, “How could I admire someone so much and live my life in such a different way from hers?”

Have you heard of the halo effect? It’s when you do the things you know are right for your body, mind, and spirit, and in doing so you begin to exude this powerfully beautiful and enticin…

Source http://feedproxy.google.com/~r/tinybuddha/~3/br57PgaLcfI/

“First you take a drink, then the drink takes a drink, then the drink takes you.” ~F. Scott Fitzgerald

I love Sophia Loren. There’s a picture of her in my home looking eternally youthful and refreshed. From what I’ve been told it’s due to her nine to ten hours of sleep each night.

When I look at this picture, I see someone who relishes in the delights of life. Food, laughter, sex, work, motherhood, and self-care. Not long ago I stared at that picture thinking, “How could I admire someone so much and live my life in such a different way from hers?”

Have you heard of the halo effect? It’s when you do the things you know are right for your body, mind, and spirit, and in doing so you begin to exude this powerfully beautiful and enticin…

Studio Owners Can Build Back Cheaper, Better in 2021

Source https://www.clubindustry.com/insights-resources/studio-owners-can-build-back-cheaper-better-2021

Studio Owners Can Build Back Cheaper, Better in 2021
pkufahl
Thu, 01/14/2021 – 11:32

Source https://www.clubindustry.com/insights-resources/studio-owners-can-build-back-cheaper-better-2021

Studio Owners Can Build Back Cheaper, Better in 2021
pkufahl
Thu, 01/14/2021 – 11:32

A Perfect Storm

Source https://changingaging.org/covid-resources/a-perfect-storm/

In at least half of the states, LTC homes are shielded to varying degrees from civil liability for COVID-19 claims. As Minnesotans are waiting to see whether the state will grant legal immunity to LTC homes, in effect, extensive COVID-19 liability shields are already in place. This fact, which does not receive adequate attention in the media, is addressed in this blog post….

Source https://changingaging.org/covid-resources/a-perfect-storm/

In at least half of the states, LTC homes are shielded to varying degrees from civil liability for COVID-19 claims. As Minnesotans are waiting to see whether the state will grant legal immunity to LTC homes, in effect, extensive COVID-19 liability shields are already in place. This fact, which does not receive adequate attention in the media, is addressed in this blog post….

1-Pot French Onion Soup (Vegan!)

Source https://minimalistbaker.com/1-pot-french-onion-soup-vegan/

1-Pot French Onion Soup (Vegan!)

After cracking the code on oil-free caramelized onions, we found ourselves craving French Onion Soup!

So we got to work creating a 1-pot, plant-based version that doesn’t skimp on flavor. Spoiler alert? Major success! Let us show you how it’s done!

Origin of French Onion Soup

As the name suggests, French onion soup originated in France. Specifically, it’s believed that King Louis XV created it for a party when he was running low on ingredients (thank goodness for onions).

<a href="https://minimalistbaker.com/1…

Source https://minimalistbaker.com/1-pot-french-onion-soup-vegan/

1-Pot French Onion Soup (Vegan!)

After cracking the code on oil-free caramelized onions, we found ourselves craving French Onion Soup!

So we got to work creating a 1-pot, plant-based version that doesn’t skimp on flavor. Spoiler alert? Major success! Let us show you how it’s done!

Origin of French Onion Soup

As the name suggests, French onion soup originated in France. Specifically, it’s believed that King Louis XV created it for a party when he was running low on ingredients (thank goodness for onions).

<a href="https://minimalistbaker.com/1…

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