Source https://www.fightaging.org/archives/2025/10/metabolomic-signatures-of-extreme-old-age/
It remains an open question as to whether studying the biochemistry of extremely old people can provide a basis for interventions that will help everyone live meaningfully longer. If genetics has little influence on longevity for the vast majority of people, as seems to be the case, then differences observed in extremely old people emerge from (a) lifestyle choices that we can control and (b) exposures that we presently have less control over, such as infectious disease burden and composition of the gut microbiome. However, any of the biochemical differences …
Source https://www.fightaging.org/archives/2025/10/metabolomic-signatures-of-extreme-old-age/
It remains an open question as to whether studying the biochemistry of extremely old people can provide a basis for interventions that will help everyone live meaningfully longer. If genetics has little influence on longevity for the vast majority of people, as seems to be the case, then differences observed in extremely old people emerge from (a) lifestyle choices that we can control and (b) exposures that we presently have less control over, such as infectious disease burden and composition of the gut microbiome. However, any of the biochemical differences …
Source https://www.theminimalists.com/guilt/
The Minimalists discuss decluttering without guilt.
What’s one item you felt guilty about getting rid of? Let us know in the YouTube comments.
Subscribe to The Minimalists via
email.
The post 5 Things You Should Never Feel Guilty About Getting Rid Of appeared first on The Minimalists.
…
Source https://www.theminimalists.com/guilt/
The Minimalists discuss decluttering without guilt.
What’s one item you felt guilty about getting rid of? Let us know in the YouTube comments.
Subscribe to The Minimalists via
email.
The post 5 Things You Should Never Feel Guilty About Getting Rid Of appeared first on The Minimalists.
…
Source https://minimalistbaker.com/easy-gluten-free-monster-cookies/
Monster Cookies have leveled up! Say hello to our healthier twist on the chewy, tender, peanut buttery, chocolate- & candy-studded cookie you know and love. Our version has all the decadence and deliciousness, but it’s vegan, gluten-free, flourless, oil-free, and maple-sweetened (magic, we know)!
Even better? These cookies are a breeze to make! You’ll need just 1 bowl, 9 ingredients, and about 20 minutes until it’s cookie time.
<a href="https://minimalistbaker.com/easy-gluten-free-monster…
Source https://minimalistbaker.com/easy-gluten-free-monster-cookies/
Monster Cookies have leveled up! Say hello to our healthier twist on the chewy, tender, peanut buttery, chocolate- & candy-studded cookie you know and love. Our version has all the decadence and deliciousness, but it’s vegan, gluten-free, flourless, oil-free, and maple-sweetened (magic, we know)!
Even better? These cookies are a breeze to make! You’ll need just 1 bowl, 9 ingredients, and about 20 minutes until it’s cookie time.
<a href="https://minimalistbaker.com/easy-gluten-free-monster…
Source https://www.fightaging.org/archives/2025/10/pharmacological-approaches-to-the-treatment-of-skeletal-muscle-aging/
Researchers here provide a tour of better known pharmacological targets for the development of drugs to slow or potentially reverse loss of muscle mass and strength with age. The high bar to beat is the effects of resistance exercise, but there is likely merit in drugs that will enhance the improvements provided by resistance exercise, provided that they have a reasonable cost. A few common themes emerge in the targets. Many approaches produce a reduction in inflammation, as chronic inflammation is strongly implicated in loss of muscle tissue maintenance and tissue function, for example. Loss of stem cell activity and issues with neuromuscular junctions are also well studied in the context of muscle aging, and the research community has sou…
Source https://www.fightaging.org/archives/2025/10/pharmacological-approaches-to-the-treatment-of-skeletal-muscle-aging/
Researchers here provide a tour of better known pharmacological targets for the development of drugs to slow or potentially reverse loss of muscle mass and strength with age. The high bar to beat is the effects of resistance exercise, but there is likely merit in drugs that will enhance the improvements provided by resistance exercise, provided that they have a reasonable cost. A few common themes emerge in the targets. Many approaches produce a reduction in inflammation, as chronic inflammation is strongly implicated in loss of muscle tissue maintenance and tissue function, for example. Loss of stem cell activity and issues with neuromuscular junctions are also well studied in the context of muscle aging, and the research community has sou…
Source https://tinybuddha.com/blog/full-circle-reclaiming-the-me-i-thought-id-lost/
“We shall not cease from exploration, and the end of all our exploring will be to arrive where we started and know the place for the first time.” ~T.S. Eliot
In my early twenties, I packed a backpack and boarded a plane alone with a one-way ticket to Southeast Asia. It was a move that baffled my father, inspired my friends, and quietly terrified me.
I was drawn by something I couldn’t fully articulate at the time: a craving for freedom, truth, and a kind of belonging I hadn’t yet known. What I didn’t realize then is that this two-year trip would imprint on me a version of myself I’d spend the next twenty years slowly forgetting, and then, almost by surprise, begin to reclaim.
Th…
Source https://tinybuddha.com/blog/full-circle-reclaiming-the-me-i-thought-id-lost/
“We shall not cease from exploration, and the end of all our exploring will be to arrive where we started and know the place for the first time.” ~T.S. Eliot
In my early twenties, I packed a backpack and boarded a plane alone with a one-way ticket to Southeast Asia. It was a move that baffled my father, inspired my friends, and quietly terrified me.
I was drawn by something I couldn’t fully articulate at the time: a craving for freedom, truth, and a kind of belonging I hadn’t yet known. What I didn’t realize then is that this two-year trip would imprint on me a version of myself I’d spend the next twenty years slowly forgetting, and then, almost by surprise, begin to reclaim.
Th…
Source https://www.theminimalists.com/p509/
The Minimalists talk about feeling defeated because of limitations, problems that won’t go away, other people’s cluttered spaces, five things you should never feel guilty about getting rid of, and more!
Listen to the Episode
Apple · Spotify · Patreon
Discussed in This Episode
- How do you cope when a recurring injury or limitation makes you feel defeated, anxious, and discouraged?
- What problem keeps popping up even after y…
Source https://www.theminimalists.com/p509/
The Minimalists talk about feeling defeated because of limitations, problems that won’t go away, other people’s cluttered spaces, five things you should never feel guilty about getting rid of, and more!
Listen to the Episode
Apple · Spotify · Patreon
Discussed in This Episode
- How do you cope when a recurring injury or limitation makes you feel defeated, anxious, and discouraged?
- What problem keeps popping up even after y…
Source https://seniorplanet.org/articles-senior-debt/
Debt among Americans going into retirement is reaching alarmingly high levels – are you one of the four in ten at high risk?
The post The Senior Debt Trap appeared first on Senior Planet from AARP.
…
Source https://seniorplanet.org/articles-senior-debt/
Debt among Americans going into retirement is reaching alarmingly high levels – are you one of the four in ten at high risk?
The post The Senior Debt Trap appeared first on Senior Planet from AARP.
…
Source https://www.fightaging.org/archives/2025/10/a-25-component-blood-biomarker-aging-clock-improves-on-9-component-phenoage/
PhenoAge is an aging clock derived from patient data on age-related changes in nine clinical chemistry markers that are easily measured via a blood sample. A number of other blood biomarker clocks have been proposed that use more markers. The clock noted here claims a modest improvement over PhenoAge when it comes to predicting mortality risk, but that requires 25 markers. The trade-off is in the cost to the patient to obtain the necessary assays versus the degree of improved performance of the clock. This tends to be true across clocks more generally, regardless of the data used. The more popular clocks based on fewer measures continue to be popular because they do not greatly underperform the more expensive clocks that require many more measures. The work here reproduces that result by showing that combining a su…
Source https://www.fightaging.org/archives/2025/10/a-25-component-blood-biomarker-aging-clock-improves-on-9-component-phenoage/
PhenoAge is an aging clock derived from patient data on age-related changes in nine clinical chemistry markers that are easily measured via a blood sample. A number of other blood biomarker clocks have been proposed that use more markers. The clock noted here claims a modest improvement over PhenoAge when it comes to predicting mortality risk, but that requires 25 markers. The trade-off is in the cost to the patient to obtain the necessary assays versus the degree of improved performance of the clock. This tends to be true across clocks more generally, regardless of the data used. The more popular clocks based on fewer measures continue to be popular because they do not greatly underperform the more expensive clocks that require many more measures. The work here reproduces that result by showing that combining a su…
Source https://www.fightaging.org/archives/2025/10/egcg-targeted-to-muscle-cells-enhances-muscle-function-in-aged-mice/
Treatments that cause issues when administered systemically (such as via oral ingestion or intravenous injection) at the doses required to place enough of the therapeutic in a specific location in the body can be made practical via methods targeting delivery to specific cells. Here, researchers use liposomes attached to a muscle-targeted peptide to deliver the polyphenol epigallocatechin gallate (EGCG) to muscle cells. EGCG is otherwise problematic, causing liver toxicity at high doses, and has low bioavailability when ingested. Nonetheless it does have interesting effects on inflammation, <a href="https://en.wikipedia.org/wiki/Lipid_…
Source https://www.fightaging.org/archives/2025/10/egcg-targeted-to-muscle-cells-enhances-muscle-function-in-aged-mice/
Treatments that cause issues when administered systemically (such as via oral ingestion or intravenous injection) at the doses required to place enough of the therapeutic in a specific location in the body can be made practical via methods targeting delivery to specific cells. Here, researchers use liposomes attached to a muscle-targeted peptide to deliver the polyphenol epigallocatechin gallate (EGCG) to muscle cells. EGCG is otherwise problematic, causing liver toxicity at high doses, and has low bioavailability when ingested. Nonetheless it does have interesting effects on inflammation, <a href="https://en.wikipedia.org/wiki/Lipid_…