I recently noted the Astera Institute’s Rejuvenome project. The work will be conducted in collaboration with the Buck Institute. It is a sizable proposal, to conduct large and rigorous mouse studies with the ultimate goal of testing combined interventions, a necessary activity that the research community and industry alike largely fail to carry out. This is a big problem in the field of aging, as aging is the outcome of a range of distinct processes of damage accumulation. Sizable degrees of rejuvenation or slowing of aging can in the long run only emerge from combinations of approaches, repairing or working around multiple forms of damage. Given this large gap in research and development, one that will never be filled by existing institutions, philanthropic efforts must step in to fill the…
I recently noted the Astera Institute’s Rejuvenome project. The work will be conducted in collaboration with the Buck Institute. It is a sizable proposal, to conduct large and rigorous mouse studies with the ultimate goal of testing combined interventions, a necessary activity that the research community and industry alike largely fail to carry out. This is a big problem in the field of aging, as aging is the outcome of a range of distinct processes of damage accumulation. Sizable degrees of rejuvenation or slowing of aging can in the long run only emerge from combinations of approaches, repairing or working around multiple forms of damage. Given this large gap in research and development, one that will never be filled by existing institutions, philanthropic efforts must step in to fill the…
One of our all-time favorite fall vegetables is the ever-versatile butternut squash! And after you try this lasagna, you’ll see why. What started as an attempt at gluten-free ravioli turned into something even more AMAZING! This new twist on classic lasagna swaps tomato sauce for a savory, creamy, butternut squash cashew sauce that pairs perfectly with lasagna noodles and sautéed kale and mushrooms.
One of our all-time favorite fall vegetables is the ever-versatile butternut squash! And after you try this lasagna, you’ll see why. What started as an attempt at gluten-free ravioli turned into something even more AMAZING! This new twist on classic lasagna swaps tomato sauce for a savory, creamy, butternut squash cashew sauce that pairs perfectly with lasagna noodles and sautéed kale and mushrooms.
“If you want others to be happy, practice compassion. If you want to be happy, practice compassion.” – His Holiness the Fourteenth Dalai Lama
Every last one of us experiences pain and suffering, and we all see it all around us. Trauma, tragedy, illness, loss—these are all unavoidable parts of being human. And even if we endure less hardship than most, we’ll still have to watch the people we love struggling, wishing we could somehow help.
We can, and it’s far simpler than we may think. We don’t need to save people, fix their problems, or change their lives. We just need to care and be there, with open arms and ears and a loving, compassio…
“If you want others to be happy, practice compassion. If you want to be happy, practice compassion.” – His Holiness the Fourteenth Dalai Lama
Every last one of us experiences pain and suffering, and we all see it all around us. Trauma, tragedy, illness, loss—these are all unavoidable parts of being human. And even if we endure less hardship than most, we’ll still have to watch the people we love struggling, wishing we could somehow help.
We can, and it’s far simpler than we may think. We don’t need to save people, fix their problems, or change their lives. We just need to care and be there, with open arms and ears and a loving, compassio…
Two simple words can make a huge difference. They can soothe, heal, connect, and inspire.
Perhaps the two most powerful words in the English language: You matter.
Far too many people don’t believe this is true. Especially since the start of the pandemic, many have felt isolated, purposeless, and some even hopeless, wondering if they’ll ever feel connected and valuable again—if they ever even have.
My new friend Cheryl Rice started this global kindness movement, the You Matter Marathon, for this very reason.
It all began back in 2016 when a colleague handed her a bus…
Two simple words can make a huge difference. They can soothe, heal, connect, and inspire.
Perhaps the two most powerful words in the English language: You matter.
Far too many people don’t believe this is true. Especially since the start of the pandemic, many have felt isolated, purposeless, and some even hopeless, wondering if they’ll ever feel connected and valuable again—if they ever even have.
My new friend Cheryl Rice started this global kindness movement, the You Matter Marathon, for this very reason.
It all began back in 2016 when a colleague handed her a bus…
This list was curated by Cree Myles, Milwaukee-based bookstagrammer and Founding Editor of All Ways Black by Penguin Random House.
There are infinite ways to be Black, and there are infinite ways to celebrate the Black experience.
One of the best ways to honor the Black voices and stories that are moving culture forward is through literature. Whether it’s nonfiction centered on social justice, culinary, <a href="/discover/di…
This list was curated by Cree Myles, Milwaukee-based bookstagrammer and Founding Editor of All Ways Black by Penguin Random House.
There are infinite ways to be Black, and there are infinite ways to celebrate the Black experience.
One of the best ways to honor the Black voices and stories that are moving culture forward is through literature. Whether it’s nonfiction centered on social justice, culinary, <a href="/discover/di…
Given a suitable delivery system, one that localizes to the desired target tissues to a far greater degree than to all other undesirable off-target tissues, the big advantage of a gene therapy is it precisely achieves the manipulation desired. It dials up or dials down expression for selected genes, alters the amount of proteins produced from those genes, and thereby changes cell behavior as a consequence – and that is all it does. One doesn’t have the endless concern about off-target effects that characterize small molecule drug development.
There are, of course, different challenges. Setting aside some adventurous technologies that won’t be deployed in therapies any time soon, manipulating a few genes at a time is the present practical upper limit on gene therapy. Further, there is no viable …
Given a suitable delivery system, one that localizes to the desired target tissues to a far greater degree than to all other undesirable off-target tissues, the big advantage of a gene therapy is it precisely achieves the manipulation desired. It dials up or dials down expression for selected genes, alters the amount of proteins produced from those genes, and thereby changes cell behavior as a consequence – and that is all it does. One doesn’t have the endless concern about off-target effects that characterize small molecule drug development.
There are, of course, different challenges. Setting aside some adventurous technologies that won’t be deployed in therapies any time soon, manipulating a few genes at a time is the present practical upper limit on gene therapy. Further, there is no viable …
Why run the same ol’ 5K when you can race through mud or basically in your birthday suit? Whether you’re looking to dress up, get slimmed, tackle obstacles, or get in on some unlimited Twinkie action, this roundup of the most incredible themed races around has something for everyone.
When putting this list together, the fun factor was first and foremost, but we also considered the swag bags, after parties, locations, charitable affiliations, and, of course, the hilarious memories you’ll collect along with your finisher medal. So, lace up those kicks, and get ready to race. We’re off!
Why run the same ol’ 5K when you can race through mud or basically in your birthday suit? Whether you’re looking to dress up, get slimmed, tackle obstacles, or get in on some unlimited Twinkie action, this roundup of the most incredible themed races around has something for everyone.
When putting this list together, the fun factor was first and foremost, but we also considered the swag bags, after parties, locations, charitable affiliations, and, of course, the hilarious memories you’ll collect along with your finisher medal. So, lace up those kicks, and get ready to race. We’re off!
The relationship between lithium intake and health is a topic of minor interest, in that no-one is going to be building a rejuvenation therapy on the basis of the mechanisms by which lithium may very modestly slow aging in short-lived species. There is some evidence for greater human life expectancy to occur in areas in which there is more lithium in the water supply, but this sort of geographical epidemiology is fraught with confounding factors relating to wealth, preferences, culture, and migration. As researchers note here, lithium has both a narrow therapeutic window and only small effects on health…
The relationship between lithium intake and health is a topic of minor interest, in that no-one is going to be building a rejuvenation therapy on the basis of the mechanisms by which lithium may very modestly slow aging in short-lived species. There is some evidence for greater human life expectancy to occur in areas in which there is more lithium in the water supply, but this sort of geographical epidemiology is fraught with confounding factors relating to wealth, preferences, culture, and migration. As researchers note here, lithium has both a narrow therapeutic window and only small effects on health…
“The only person you can now or ever change is yourself. The only person that it is your business to control is yourself.” ~Melody Beattie
In 2019, I decided to leave my marriage and start over. Although my relationship with my ex-husband brought deep pain and many months of suffering, I felt content with my decision.
In a short time, I began to feel great. I developed a healthy routine, exercised regularly, began meditating every day, spent time in nature, maintained healthy and deep connections with people, and tried to focus on the positive.
For a few months, it seemed to be working. Until I met a man and got emotionally involved with him. I realized then I’d really been living in denial.
The moment I began dating or seeing someone more in…
“The only person you can now or ever change is yourself. The only person that it is your business to control is yourself.” ~Melody Beattie
In 2019, I decided to leave my marriage and start over. Although my relationship with my ex-husband brought deep pain and many months of suffering, I felt content with my decision.
In a short time, I began to feel great. I developed a healthy routine, exercised regularly, began meditating every day, spent time in nature, maintained healthy and deep connections with people, and tried to focus on the positive.
For a few months, it seemed to be working. Until I met a man and got emotionally involved with him. I realized then I’d really been living in denial.
The moment I began dating or seeing someone more in…
