Researchers here mine a very large data set to establish whether age-related diseases linked to a specific underlying single causative mechanism of aging will show up together in patients more often than not. One would expect that they will. To pick one example, multiple age-related diseases appear likely to be primarily caused by the increased presence of senescent cells in old tissues. A patient’s senescent cell burden will thus largely determine the risk of suffering from all of those conditions. Patients exhibiting one condition, most likely because they have more senescent cells than their healthier peers, should be more likely to also exhibit other conditions in that set.
Researchers here mine a very large data set to establish whether age-related diseases linked to a specific underlying single causative mechanism of aging will show up together in patients more often than not. One would expect that they will. To pick one example, multiple age-related diseases appear likely to be primarily caused by the increased presence of senescent cells in old tissues. A patient’s senescent cell burden will thus largely determine the risk of suffering from all of those conditions. Patients exhibiting one condition, most likely because they have more senescent cells than their healthier peers, should be more likely to also exhibit other conditions in that set.
One of the many frontiers of development in regenerative medicine is the delivery of cells engineered to overexpress one or more specific proteins in order to adjust cell function and activity in a favorable direction. Here, researchers demonstrate that making cardiomyocytes express cyclin D2 before transplantation into an animal model of a heart attack produces beneficial regeneration. The heart is a poorly regenerative organ, and any injury results in scarring and reduced capacity at best. The engineered cardiomyocytes survive following transplantation to some degree, but also produce signaling that provokes greater regenera…
One of the many frontiers of development in regenerative medicine is the delivery of cells engineered to overexpress one or more specific proteins in order to adjust cell function and activity in a favorable direction. Here, researchers demonstrate that making cardiomyocytes express cyclin D2 before transplantation into an animal model of a heart attack produces beneficial regeneration. The heart is a poorly regenerative organ, and any injury results in scarring and reduced capacity at best. The engineered cardiomyocytes survive following transplantation to some degree, but also produce signaling that provokes greater regenera…
We recently tried a store-bought vegan chorizo sausage and couldn’t believe how much it tasted like the real thing (or dare we say, even better)! But since we weren’t fans of some of the ingredients used in the store-bought version, we got to work creating an equally delicious homemade version. Spoiler alert? Major success!
It’s gluten-free, plant-based,and SO quick & easy to prepare!
We recently tried a store-bought vegan chorizo sausage and couldn’t believe how much it tasted like the real thing (or dare we say, even better)! But since we weren’t fans of some of the ingredients used in the store-bought version, we got to work creating an equally delicious homemade version. Spoiler alert? Major success!
It’s gluten-free, plant-based,and SO quick & easy to prepare!
“Don’t force yourself to fit where you don’t belong.” ~Unknown
When I was young, I was a real daddy’s girl. He was so proud of me and took me everywhere with him.
When my parents got divorced and my dad moved away to start a new life with a new family, I didn’t understand why he left, as I was still a child. I thought that he didn’t love me anymore. I felt abandoned and rejected. Perhaps if I’d been better behaved, prettier, cleverer then he wouldn’t have left me?
Until recently, I didn’t realize the impact that this has had on my adult relationships.
Because I fear abandonment and rejection, I’ve struggled to fit in and make friends.
I had a relationship with an older man who was very similar to my dad. I hoped that he would provi…
“Don’t force yourself to fit where you don’t belong.” ~Unknown
When I was young, I was a real daddy’s girl. He was so proud of me and took me everywhere with him.
When my parents got divorced and my dad moved away to start a new life with a new family, I didn’t understand why he left, as I was still a child. I thought that he didn’t love me anymore. I felt abandoned and rejected. Perhaps if I’d been better behaved, prettier, cleverer then he wouldn’t have left me?
Until recently, I didn’t realize the impact that this has had on my adult relationships.
Because I fear abandonment and rejection, I’ve struggled to fit in and make friends.
I had a relationship with an older man who was very similar to my dad. I hoped that he would provi…
There is some interest in the research community in targeting first generation stem cell therapies to the skin in order to reverse skin aging. These stem cell therapies use cells obtained from fat tissue or other well established sources, and in near all cases the transplanted cells near all die quite quickly following their introduction into the patient. Methods of cell production and sources of cells vary widely, and so do the observed benefits. Increased regeneration is widely claimed, but only intermittently proven. Benefits realized by patients largely derive from reductions in systemic inflammation and other effects on cell behavior resulting from the signaling provided briefly by the transplanted stem cells.
Today’s open access paper on stem cell therapy in the context of the treatment of pho…
There is some interest in the research community in targeting first generation stem cell therapies to the skin in order to reverse skin aging. These stem cell therapies use cells obtained from fat tissue or other well established sources, and in near all cases the transplanted cells near all die quite quickly following their introduction into the patient. Methods of cell production and sources of cells vary widely, and so do the observed benefits. Increased regeneration is widely claimed, but only intermittently proven. Benefits realized by patients largely derive from reductions in systemic inflammation and other effects on cell behavior resulting from the signaling provided briefly by the transplanted stem cells.
Today’s open access paper on stem cell therapy in the context of the treatment of pho…
The beard ain’t going nowhere. Cherub-faced naysayers have been predicting that facial hair will go out of style for decades, but we lumberjacks know better. So how do you care for your massive chin wig?
Like, did you know you can make homemade beard oil?
The beard ain’t going nowhere. Cherub-faced naysayers have been predicting that facial hair will go out of style for decades, but we lumberjacks know better. So how do you care for your massive chin wig?
Like, did you know you can make homemade beard oil?
The “Sunday Scaries” hit hardest on Sunday nights, after dinner, once the reality sets in that the weekend will expire in just a few hours and the prospect of another long work week filled with obligations lies ahead. That’s why my boyfriend and I started a Sunday night routine to look forward to in the form of a sweet and easy-to-prepare dessert: the humble mug cake.
I stumbled upon mug cakes years ago in the baking aisle and fell in love with the idea of a pre-portioned dessert for one as the perfect solution for someone like myself who loves baked goods, but had only one roommate and often found myself short on time.
The “Sunday Scaries” hit hardest on Sunday nights, after dinner, once the reality sets in that the weekend will expire in just a few hours and the prospect of another long work week filled with obligations lies ahead. That’s why my boyfriend and I started a Sunday night routine to look forward to in the form of a sweet and easy-to-prepare dessert: the humble mug cake.
I stumbled upon mug cakes years ago in the baking aisle and fell in love with the idea of a pre-portioned dessert for one as the perfect solution for someone like myself who loves baked goods, but had only one roommate and often found myself short on time.
At the beginning of the COVID-19 pandemic, I got it in my head that I wanted a pool. Having spent the majority of my formative years living in California, my parents and I had pools in a few of the different houses we rented — although I rarely swam in them due to complaints around “bees” or “my huge pad.” So, I decided that since I owned a home, which is smack dab in the hotter-than-actual-hell city of New Orleans, Louisiana, I should, and could (big question mark) have a pool now.
After I Googled how much it would cost to have an in-ground pool installed (at LEAST $30,000, including labor), that fantasy dwindled. Not to mention the fact that digging any kind of hole in the New Orleans ground is a risky move. [There’s a reason why our dead are buried in above-ground tombs here.]
I thought a pool just wasn’t in the cards for me and prepared to move on to some other kind of annoying obsession. So, I started a savings account called …
At the beginning of the COVID-19 pandemic, I got it in my head that I wanted a pool. Having spent the majority of my formative years living in California, my parents and I had pools in a few of the different houses we rented — although I rarely swam in them due to complaints around “bees” or “my huge pad.” So, I decided that since I owned a home, which is smack dab in the hotter-than-actual-hell city of New Orleans, Louisiana, I should, and could (big question mark) have a pool now.
After I Googled how much it would cost to have an in-ground pool installed (at LEAST $30,000, including labor), that fantasy dwindled. Not to mention the fact that digging any kind of hole in the New Orleans ground is a risky move. [There’s a reason why our dead are buried in above-ground tombs here.]
I thought a pool just wasn’t in the cards for me and prepared to move on to some other kind of annoying obsession. So, I started a savings account called …
In today’s open access paper, the authors report on inroads in counting senescentimmune cells in blood samples from human patients of different ages. Accurate determination of senescence status isn’t cut and dried for many types of immune cell, but the researchers believe they have produced good numbers for cytotoxic T cells, showing that older people have many more senescent cells in this category. I’d like to see more of this sort of research, establishing some sort of baseline of expectations for levels of cellular senescence in various tissues by age, leading towards assays that can be used to directly the measure the outcome of treatment with senolytic drugs to selectively destroy se…
In today’s open access paper, the authors report on inroads in counting senescentimmune cells in blood samples from human patients of different ages. Accurate determination of senescence status isn’t cut and dried for many types of immune cell, but the researchers believe they have produced good numbers for cytotoxic T cells, showing that older people have many more senescent cells in this category. I’d like to see more of this sort of research, establishing some sort of baseline of expectations for levels of cellular senescence in various tissues by age, leading towards assays that can be used to directly the measure the outcome of treatment with senolytic drugs to selectively destroy se…
