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Source https://www.fightaging.org/archives/2021/11/the-age-related-decline-of-energy-metabolism-in-myeloid-cells-as-an-important-cause-of-neurodegeneration/

Today’s open access editorial discusses one quite specific consequence of the age-related disruption of energy metabolism in cells. Mitochondria, the power plants of the cell, falter with age throughout the body, for complex reasons still under exploration. The proximate causes involve too little production of molecular machinery needed for the correct operation of the electron transport chain, or mitochondrial dynamics, in the first case leading to inefficient production of ATP and raised levels of reactive oxygen species, and in the second case leading to failure of quality control mechanisms intended to rem…

Source https://www.fightaging.org/archives/2021/11/the-longevity-biotech-association-launches/

At first glance, with only a few exceptions in the initial membership, the newly launched Longevity Biotech Association is an advocacy group for the small molecule, stress response upregulation faction within the development community focused on the treatment of aging as a medical condition. More advocacy for the concept and feasibility of treating aging is certainly a good thing, and it is welcome to see the arrival of new high-profile initiatives. A cautionary thought is that the only real merit of the small molecule stress response upregulation approach, mimicking thin slices of the beneficial metabolic response to exercise, calorie restriction, heat, cold, or…

Source https://tinybuddha.com/blog/making-big-decisions-how-to-discern-the-whispers-of-soul/

“Intuition is the whisper of the soul.” ~Jiddu Krishnamurti

“I can’t believe they are taking her side over mine. I gave this job so many years, and she decides to walk in and mess it all up for me,” I said to my husband.

A few years back, when I was working full time at my corporate job, I got into a disagreement with a team member. It spiraled out of control to the point where my boss then had to have a sit-down with us. I was so humiliated and angry that he could not see my side.

They will realize when they lose you, whispered my ego.

That was when I decided to leave. I started to look for new jobs and got offers.

Now here is the thing—I did have a great job, I had a great team, no long hours…

Source https://www.fightaging.org/archives/2021/11/a-senolytic-treatment-improves-visual-function-in-a-small-trial-for-macular-degeneration/

UNITY Biotechnology recently reported positive results for their senolytic drug candidate UBX1325, probably derived from navitoclax. Senolytic therapies selectively destroy senescent cells in aged tissues, reducing their inflammatory signaling and contribution to tissue dysfunction. In this case, macular degeneration patients showed improved visual function after treatment, though one should wait for a larger study group before calling this an unqualified success. UNITY Biotechnology’s trials are essentially testing the thesis that localized removal of senescent cells can address pathology, and thus low, localized doses of chemotherapeutic-derived senolytic drugs can be used, minimizing side-effects. In this case, the senolytic is injected into the…

Source https://seniorplanet.org/prediabetes-a-hidden-condition/

One American in three has prediabetes, but doesn’t know it. Get the facts here on this hidden health challenge.

The post Prediabetes – A Hidden Condition appeared first on Senior Planet.

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Source https://www.fightaging.org/archives/2021/11/some-cell-therapies-reduce-inflammation-precisely-because-the-transplanted-cells-die/

First generation stem cell therapies have been demonstrated to reduce chronic inflammation, but are unreliable when it comes to producing other benefits. Since very few transplanted cells survive, it was thought that benefits are produced via signaling that changes the behavior of native cells. This has led to work on therapies that deliver extracellular vesicles released by stem cells rather than the cells themselves. That such therapies produce benefits in similar ways to stem cell therapies in <a href="https://en.wikipedia.org/wiki/Animal_mo…

Source https://www.ageinplacetech.com/blog/smart-homes-older-adults-connected-intelligent-healthy

Source https://www.clubindustry.com/company/hugo-braam-virtuagym

Hugo Braam, Virtuagym
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Fri, 06/25/2021 – 16:21

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Source https://www.fightaging.org/archives/2021/11/looking-deeper-into-age-related-changes-in-the-skin-microbiome/

For reasons yet to be determined, the composition of the skin microbiome changes with age. It is also unclear as to whether these changes contribute to skin aging in any meaningful way, or are instead a consequence of skin aging. Researchers here perform a proof of concept study to identify bacterial activities that differ in the microbiome of old versus young skin. There is little to be learned from these initial results, but in principle a much more comprehensive set of data might point the way towards specific experiments that could be conducted, changing the balance of populations in the skin microbiome in measured ways to see if the function of aged skin improves as a result.

The human skin is inhabited by a large number and variety of microorganisms, including bacteria, fungi, and viruses. Although over- and underrepresented bacter…