Category: Health and Fitness

A Decline in Stemness in Many Human Stem Cell Populations with Aging

Source https://www.fightaging.org/archives/2024/04/a-decline-in-stemness-in-many-human-stem-cell-populations-with-aging/

Like the accumulation of senescent cells, loss of stem cell function is a problematic feature of aging. Also like the accumulation of senescent cells, loss of stem cell function is likely downstream of a combination of forms of molecular damage and consequent changes in cell behavior and cell signaling that are presently incompletely understood in detail and harder to address. Senescent cells can be cleared more readily than prevented, and stem cells may be more readily coerced into activity…

Source https://www.fightaging.org/archives/2024/04/a-decline-in-stemness-in-many-human-stem-cell-populations-with-aging/

Like the accumulation of senescent cells, loss of stem cell function is a problematic feature of aging. Also like the accumulation of senescent cells, loss of stem cell function is likely downstream of a combination of forms of molecular damage and consequent changes in cell behavior and cell signaling that are presently incompletely understood in detail and harder to address. Senescent cells can be cleared more readily than prevented, and stem cells may be more readily coerced into activity…

The Role of Immune Aging in Neurodegenerative Conditions

Source https://www.fightaging.org/archives/2024/04/the-role-of-immune-aging-in-neurodegenerative-conditions/

The research community has come to see chronic inflammation and other age-related immune system dysfunctions as an important aspect of neurodegenerative conditions. Inflammation in the short term is necessary for defense against pathogens and regeneration following injury. Unresolved, constant inflammation is harmful to tissue structure and function, however, changing cell behavior for the worse. In brain tissue, the effects of inflammatory signaling on the behavior of innate immune cells called microglia appears particula…

Source https://www.fightaging.org/archives/2024/04/the-role-of-immune-aging-in-neurodegenerative-conditions/

The research community has come to see chronic inflammation and other age-related immune system dysfunctions as an important aspect of neurodegenerative conditions. Inflammation in the short term is necessary for defense against pathogens and regeneration following injury. Unresolved, constant inflammation is harmful to tissue structure and function, however, changing cell behavior for the worse. In brain tissue, the effects of inflammatory signaling on the behavior of innate immune cells called microglia appears particula…

Simple Sun-Dried Tomato Hummus

Source https://minimalistbaker.com/simple-sun-dried-tomato-hummus/

Simple Sun-Dried Tomato Hummus

If you love hummus and the rich flavor of tomatoes, you’ll ADORE this simple sun-dried tomato hummus. It’s SO versatile, creamy, easy to make, and adds instant flavor to just about everything. Enjoy it on pita, veggies, crackers, sandwiches, and more.

It’s perfect for parties, picnics, meal prep, road trips, and everything in between! Just 15 minutes and a food processor or blender required. Let’s make hummus!

This recipe is adapted from the Simple Sun-Dried Tomato Hummus in our cookbook!

Simple Sun-Dried Tomato Hummus from Minimalist Baker →</a…

Source https://minimalistbaker.com/simple-sun-dried-tomato-hummus/

Simple Sun-Dried Tomato Hummus

If you love hummus and the rich flavor of tomatoes, you’ll ADORE this simple sun-dried tomato hummus. It’s SO versatile, creamy, easy to make, and adds instant flavor to just about everything. Enjoy it on pita, veggies, crackers, sandwiches, and more.

It’s perfect for parties, picnics, meal prep, road trips, and everything in between! Just 15 minutes and a food processor or blender required. Let’s make hummus!

This recipe is adapted from the Simple Sun-Dried Tomato Hummus in our cookbook!

Simple Sun-Dried Tomato Hummus from Minimalist Baker →</a…

Investigating the Mechanisms of Very Early Alzheimer's Disease

Source https://www.fightaging.org/archives/2024/04/investigating-the-mechanisms-of-very-early-alzheimers-disease/

Researchers here look at cellular dysfunction that may form the earliest stages of Alzheimer’s disease, prior to the accumulation of misfolded amyloid-β and cognitive decline. In general, intervening early in the progression of a disease will always be easier, given the right target. The challenge lies in identifying and understanding the causative mechanisms, in an environment in which (a) there is little access to brain tissue in the earliest stages of Alzheimer’s disease, and (b) the animal models are highly artificial, as mice do not normally develop anything resembling Alzheimer’s disease, and thus may not accurately reflect important aspects of the human condition.

<a href="https://en.wikipedia.org/wiki/Amyl…

Source https://www.fightaging.org/archives/2024/04/investigating-the-mechanisms-of-very-early-alzheimers-disease/

Researchers here look at cellular dysfunction that may form the earliest stages of Alzheimer’s disease, prior to the accumulation of misfolded amyloid-β and cognitive decline. In general, intervening early in the progression of a disease will always be easier, given the right target. The challenge lies in identifying and understanding the causative mechanisms, in an environment in which (a) there is little access to brain tissue in the earliest stages of Alzheimer’s disease, and (b) the animal models are highly artificial, as mice do not normally develop anything resembling Alzheimer’s disease, and thus may not accurately reflect important aspects of the human condition.

<a href="https://en.wikipedia.org/wiki/Amyl…

Ambitious Goals at Mitrix Bio

Source https://www.fightaging.org/archives/2024/04/ambitious-goals-at-mitrix-bio/

Mitrix Bio is one of the companies developing the means to produce large amounts of mitochondria for transplantation. Cells will take up new mitochondria from the surrounding environment, and mitochondria can be harvested from cell cultures. Mitochondrial function declines with age, the result of (a) gene expression changes in the cell nucleus that alter mitochondrial dynamics and the quality control process of mitophagy, and (b) <a href="https://www.fightaging.org/archives/2006/10/how-age-damaged-mitochondria-cause-your-cells-to-damage…

Source https://www.fightaging.org/archives/2024/04/ambitious-goals-at-mitrix-bio/

Mitrix Bio is one of the companies developing the means to produce large amounts of mitochondria for transplantation. Cells will take up new mitochondria from the surrounding environment, and mitochondria can be harvested from cell cultures. Mitochondrial function declines with age, the result of (a) gene expression changes in the cell nucleus that alter mitochondrial dynamics and the quality control process of mitophagy, and (b) <a href="https://www.fightaging.org/archives/2006/10/how-age-damaged-mitochondria-cause-your-cells-to-damage…

6 Reasons We Ignore Our Needs and How to Stop

Source https://tinybuddha.com/blog/6-reasons-we-ignore-our-needs-and-how-to-stop/

“If you feel that you are missing out on fulfillment and happiness, but cannot put your finger on why, perhaps there is something deeper going on. Believe it or not, anyone can develop an unconscious habit of self-deprivation. Usually, this habit begins in childhood.” ~Mike Bundrant

For all my adolescence and over a decade of my adult life, I was what men (and I’m guessing some female friends as well) would refer to as “emotionally needy.” And some did. To my face. With a sense of condescension and judgment.

They were right. I was clingy, insecure, and fragile. I needed regular reassurance. And I was constantly on the lookout for signs that someone might reject or abandon me.

<p style="font-weight: …

Source https://tinybuddha.com/blog/6-reasons-we-ignore-our-needs-and-how-to-stop/

“If you feel that you are missing out on fulfillment and happiness, but cannot put your finger on why, perhaps there is something deeper going on. Believe it or not, anyone can develop an unconscious habit of self-deprivation. Usually, this habit begins in childhood.” ~Mike Bundrant

For all my adolescence and over a decade of my adult life, I was what men (and I’m guessing some female friends as well) would refer to as “emotionally needy.” And some did. To my face. With a sense of condescension and judgment.

They were right. I was clingy, insecure, and fragile. I needed regular reassurance. And I was constantly on the lookout for signs that someone might reject or abandon me.

<p style="font-weight: …

Podcast 440 | Memory Clutter

Source https://www.theminimalists.com/p440/

In this public episode of The Minimalists Podcast, The Minimalists discuss letting go of memories, creating an uncluttered home, three new series from The Minimalists, and more. Listen to the full Maximal episode on The Minimalists Private Podcast.

Subscribe

Apple · Spotify · YouTube · Patreon · MP3

Discussed in This Episode

  • <span sty…

Source https://www.theminimalists.com/p440/

In this public episode of The Minimalists Podcast, The Minimalists discuss letting go of memories, creating an uncluttered home, three new series from The Minimalists, and more. Listen to the full Maximal episode on The Minimalists Private Podcast.

Subscribe

Apple · Spotify · YouTube · Patreon · MP3

Discussed in This Episode

  • <span sty…

Go Green – and Get Social!

Source https://seniorplanet.org/articles-social-green/

This year one billion people in 193 countries will participate in Earth Day activities on April 22, with many ways to work with others.

The post Go Green – and Get Social! appeared first on Senior Planet from AARP.

…

Source https://seniorplanet.org/articles-social-green/

This year one billion people in 193 countries will participate in Earth Day activities on April 22, with many ways to work with others.

The post Go Green – and Get Social! appeared first on Senior Planet from AARP.

…

How My Wellness Passion Was Actually Destroying My Health

Source https://tinybuddha.com/blog/how-my-wellness-passion-was-actually-destroying-my-health/

“Your body holds deep wisdom. Trust in it. Learn from it. Nourish it. Watch your life transform and be healthy.” ~Bella Bleue

It didn’t fit. I zipped, tugged, and shimmied, but the zipper wouldn’t budge. I was twenty-three, it was my college graduation, and the dress I had bought a month ago would not zip.

As I stood there crying in the mirror, riddled with exhaustion, anxiety, vulnerability, and sheer overwhelm, I wondered what was happening to my body. In just one month I had gained thirty pounds. I was having one to three panic attacks a day. Everything I ate made me sick, and no matter how much I worked out, I only felt w…

Source https://tinybuddha.com/blog/how-my-wellness-passion-was-actually-destroying-my-health/

“Your body holds deep wisdom. Trust in it. Learn from it. Nourish it. Watch your life transform and be healthy.” ~Bella Bleue

It didn’t fit. I zipped, tugged, and shimmied, but the zipper wouldn’t budge. I was twenty-three, it was my college graduation, and the dress I had bought a month ago would not zip.

As I stood there crying in the mirror, riddled with exhaustion, anxiety, vulnerability, and sheer overwhelm, I wondered what was happening to my body. In just one month I had gained thirty pounds. I was having one to three panic attacks a day. Everything I ate made me sick, and no matter how much I worked out, I only felt w…

Fight Aging! Newsletter, April 22nd 2024

Source https://www.fightaging.org/archives/2024/04/fight-aging-newsletter-april-22nd-2024/

Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/

Longevity Industry Consulting Services

Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out more: https://www.fightaging.org/services/


Contents

Source https://www.fightaging.org/archives/2024/04/fight-aging-newsletter-april-22nd-2024/

Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/

Longevity Industry Consulting Services

Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out more: https://www.fightaging.org/services/


Contents

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