Senior Planet Book Club: The Lost Vintage (Week 1)

Source https://seniorplanet.org/senior-planet-book-club-the-lost-vintage-week-1/

The votes are in!

The post Senior Planet Book Club: <em>The Lost Vintage</em> (Week 1) appeared first on Senior Planet.

Source https://seniorplanet.org/senior-planet-book-club-the-lost-vintage-week-1/

The votes are in!

The post Senior Planet Book Club: <em>The Lost Vintage</em> (Week 1) appeared first on Senior Planet.

Magnesium-Rich Foods: How to Get More of This Magnificent Mineral

Source https://greatist.com/health/magnesium-foods

Magnesium is a jack-of-all-trades nutrient. Your body needs it for muscle contraction, neurotransmitter release, energy production, nerve function, bone development… you get the idea, it’s a must-have for your health.

pumpkin seeds
Sean Locke/Stocksy United

Which foods have the most magnesium?

It’s common to get less than the recommended 310 to 420 milligrams…

Source https://greatist.com/health/magnesium-foods

Magnesium is a jack-of-all-trades nutrient. Your body needs it for muscle contraction, neurotransmitter release, energy production, nerve function, bone development… you get the idea, it’s a must-have for your health.

pumpkin seeds
Sean Locke/Stocksy United

Which foods have the most magnesium?

It’s common to get less than the recommended 310 to 420 milligrams…

The Age-Related Decline of Energy Metabolism in Myeloid Cells as an Important Cause of Neurodegeneration

Source https://www.fightaging.org/archives/2021/11/the-age-related-decline-of-energy-metabolism-in-myeloid-cells-as-an-important-cause-of-neurodegeneration/

Today’s open access editorial discusses one quite specific consequence of the age-related disruption of energy metabolism in cells. Mitochondria, the power plants of the cell, falter with age throughout the body, for complex reasons still under exploration. The proximate causes involve too little production of molecular machinery needed for the correct operation of the electron transport chain, or mitochondrial dynamics, in the first case leading to inefficient production of ATP and raised levels of reactive oxygen species, and in the second case leading to failure of quality control mechanisms intended to rem…

Source https://www.fightaging.org/archives/2021/11/the-age-related-decline-of-energy-metabolism-in-myeloid-cells-as-an-important-cause-of-neurodegeneration/

Today’s open access editorial discusses one quite specific consequence of the age-related disruption of energy metabolism in cells. Mitochondria, the power plants of the cell, falter with age throughout the body, for complex reasons still under exploration. The proximate causes involve too little production of molecular machinery needed for the correct operation of the electron transport chain, or mitochondrial dynamics, in the first case leading to inefficient production of ATP and raised levels of reactive oxygen species, and in the second case leading to failure of quality control mechanisms intended to rem…

The Longevity Biotech Association Launches

Source https://www.fightaging.org/archives/2021/11/the-longevity-biotech-association-launches/

At first glance, with only a few exceptions in the initial membership, the newly launched Longevity Biotech Association is an advocacy group for the small molecule, stress response upregulation faction within the development community focused on the treatment of aging as a medical condition. More advocacy for the concept and feasibility of treating aging is certainly a good thing, and it is welcome to see the arrival of new high-profile initiatives. A cautionary thought is that the only real merit of the small molecule stress response upregulation approach, mimicking thin slices of the beneficial metabolic response to exercise, calorie restriction, heat, cold, or…

Source https://www.fightaging.org/archives/2021/11/the-longevity-biotech-association-launches/

At first glance, with only a few exceptions in the initial membership, the newly launched Longevity Biotech Association is an advocacy group for the small molecule, stress response upregulation faction within the development community focused on the treatment of aging as a medical condition. More advocacy for the concept and feasibility of treating aging is certainly a good thing, and it is welcome to see the arrival of new high-profile initiatives. A cautionary thought is that the only real merit of the small molecule stress response upregulation approach, mimicking thin slices of the beneficial metabolic response to exercise, calorie restriction, heat, cold, or…

Making Big Decisions: How to Discern the Whispers of Soul

Source https://tinybuddha.com/blog/making-big-decisions-how-to-discern-the-whispers-of-soul/

“Intuition is the whisper of the soul.” ~Jiddu Krishnamurti

“I can’t believe they are taking her side over mine. I gave this job so many years, and she decides to walk in and mess it all up for me,” I said to my husband.

A few years back, when I was working full time at my corporate job, I got into a disagreement with a team member. It spiraled out of control to the point where my boss then had to have a sit-down with us. I was so humiliated and angry that he could not see my side.

They will realize when they lose you, whispered my ego.

That was when I decided to leave. I started to look for new jobs and got offers.

Now here is the thing—I did have a great job, I had a great team, no long hours…

Source https://tinybuddha.com/blog/making-big-decisions-how-to-discern-the-whispers-of-soul/

“Intuition is the whisper of the soul.” ~Jiddu Krishnamurti

“I can’t believe they are taking her side over mine. I gave this job so many years, and she decides to walk in and mess it all up for me,” I said to my husband.

A few years back, when I was working full time at my corporate job, I got into a disagreement with a team member. It spiraled out of control to the point where my boss then had to have a sit-down with us. I was so humiliated and angry that he could not see my side.

They will realize when they lose you, whispered my ego.

That was when I decided to leave. I started to look for new jobs and got offers.

Now here is the thing—I did have a great job, I had a great team, no long hours…

A Senolytic Treatment Improves Visual Function in a Small Trial for Macular Degeneration

Source https://www.fightaging.org/archives/2021/11/a-senolytic-treatment-improves-visual-function-in-a-small-trial-for-macular-degeneration/

UNITY Biotechnology recently reported positive results for their senolytic drug candidate UBX1325, probably derived from navitoclax. Senolytic therapies selectively destroy senescent cells in aged tissues, reducing their inflammatory signaling and contribution to tissue dysfunction. In this case, macular degeneration patients showed improved visual function after treatment, though one should wait for a larger study group before calling this an unqualified success. UNITY Biotechnology’s trials are essentially testing the thesis that localized removal of senescent cells can address pathology, and thus low, localized doses of chemotherapeutic-derived senolytic drugs can be used, minimizing side-effects. In this case, the senolytic is injected into the…

Source https://www.fightaging.org/archives/2021/11/a-senolytic-treatment-improves-visual-function-in-a-small-trial-for-macular-degeneration/

UNITY Biotechnology recently reported positive results for their senolytic drug candidate UBX1325, probably derived from navitoclax. Senolytic therapies selectively destroy senescent cells in aged tissues, reducing their inflammatory signaling and contribution to tissue dysfunction. In this case, macular degeneration patients showed improved visual function after treatment, though one should wait for a larger study group before calling this an unqualified success. UNITY Biotechnology’s trials are essentially testing the thesis that localized removal of senescent cells can address pathology, and thus low, localized doses of chemotherapeutic-derived senolytic drugs can be used, minimizing side-effects. In this case, the senolytic is injected into the…

Prediabetes – A Hidden Condition

Source https://seniorplanet.org/prediabetes-a-hidden-condition/

One American in three has prediabetes, but doesn’t know it. Get the facts here on this hidden health challenge.

The post Prediabetes – A Hidden Condition appeared first on Senior Planet.

Source https://seniorplanet.org/prediabetes-a-hidden-condition/

One American in three has prediabetes, but doesn’t know it. Get the facts here on this hidden health challenge.

The post Prediabetes – A Hidden Condition appeared first on Senior Planet.

Some Cell Therapies Reduce Inflammation Precisely Because the Transplanted Cells Die

Source https://www.fightaging.org/archives/2021/11/some-cell-therapies-reduce-inflammation-precisely-because-the-transplanted-cells-die/

First generation stem cell therapies have been demonstrated to reduce chronic inflammation, but are unreliable when it comes to producing other benefits. Since very few transplanted cells survive, it was thought that benefits are produced via signaling that changes the behavior of native cells. This has led to work on therapies that deliver extracellular vesicles released by stem cells rather than the cells themselves. That such therapies produce benefits in similar ways to stem cell therapies in <a href="https://en.wikipedia.org/wiki/Animal_mo…

Source https://www.fightaging.org/archives/2021/11/some-cell-therapies-reduce-inflammation-precisely-because-the-transplanted-cells-die/

First generation stem cell therapies have been demonstrated to reduce chronic inflammation, but are unreliable when it comes to producing other benefits. Since very few transplanted cells survive, it was thought that benefits are produced via signaling that changes the behavior of native cells. This has led to work on therapies that deliver extracellular vesicles released by stem cells rather than the cells themselves. That such therapies produce benefits in similar ways to stem cell therapies in <a href="https://en.wikipedia.org/wiki/Animal_mo…

Smart homes for older adults – connected, intelligent, healthy?

Source https://www.ageinplacetech.com/blog/smart-homes-older-adults-connected-intelligent-healthy

What is a Smart Home? Should it be Connected? Gartner Research defines the Connected Home as: “Networked to enable the interconnection and interoperability of multiple devices, services and apps, ranging from communications and entertainment to healthcare, security and home automation. These services and apps are delivered over multiple interlinked and integrated devices, sensors, tools and platforms. Connected, real-time, smart and contextual experiences are provided for the household inhab…

Source https://www.ageinplacetech.com/blog/smart-homes-older-adults-connected-intelligent-healthy

What is a Smart Home? Should it be Connected? Gartner Research defines the Connected Home as: “Networked to enable the interconnection and interoperability of multiple devices, services and apps, ranging from communications and entertainment to healthcare, security and home automation. These services and apps are delivered over multiple interlinked and integrated devices, sensors, tools and platforms. Connected, real-time, smart and contextual experiences are provided for the household inhab…

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