Cognitively Healthy Centenarians are Resistant to Age-Related Brain Pathology

Source https://www.fightaging.org/archives/2022/10/cognitively-healthy-centenarians-are-resistant-to-age-related-brain-pathology/

The article here notes that researchers find cognitively healthy centenarians exhibit levels of protein aggregation and other brain lesions typical of people showing symptoms of neurodegenerative diseases. They are in some way more resistant, but why this is the case is a continuing research project. It is possible to identify specific gene variants and more youthful gene expression for some genes in cognitively healthy older individuals, but it is long trek from that data to an understanding of the mechanisms involved.

Researchers initially aimed to recruit 500 cognitively healthy centenarians. As of June 2021, 406 had signed up. Their average age when they joined was 1…

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