Enhancer DNA Sequence from Zebrafish Can Induce Targeted Heart Regeneration in Mice

Source https://www.fightaging.org/archives/2022/12/enhancer-dna-sequence-from-zebrafish-can-induce-targeted-heart-regeneration-in-mice/

This very interesting work involves identifying enhancer DNA sequences that regulate regeneration in an exceptionally regenerative species, such as zebrafish, and introducing these sequences into mammals via gene therapy. The researchers find a sequence that can be used to regulate expression of genes that drive heart regeneration following injury, a desirable goal given that mammalian hearts regenerate poorly. Zebrafish are capable of scarless healing of heart injuries, and connecting the zebrafish enhancer to mammalian growth genes can improve regeneration, by expressing these genes at the appropriate time in the context of repair of injury.

Researchers borrowed…

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