Increased Expression of Lysosomal Enzyme NAGLU Improves Health in Flies

Source https://www.fightaging.org/archives/2022/12/increased-expression-of-lysosomal-enzyme-naglu-improves-health-in-flies/

Lysosomes are the destination for excess and damaged proteins and structures in the cell. A lysosome is a membrane-wrapped collection of enzymes capable of breaking down near everything it encounters into the raw materials a cell uses to manufacture new molecular machinery. Lysosomal function is known to decline with age, and improved lysosomal function might be expected to improve long-term health prospects. Here, researchers look at one specific lysosomal enzyme that is known to exhibit higher levels in human centenarians, and find that it improves health in flies. There is extension of life, but the effect size is so small, a few percentage points, that it shouldn’t be taken seriously.

To identify new factors that promote longevity and healthy aging, we studied <a href="https://en.wikipedia…

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