Nicotinamide Riboside Supplementation Beginning in Mid-Life Slows Osteoporosis in Mice

Source https://www.fightaging.org/archives/2021/04/nicotinamide-riboside-supplementation-beginning-in-mid-life-slows-osteoporosis-in-mice/

In today’s open access paper, researchers report that long-term supplementation with nicotinamide riboside in mice, starting from mid-life and continuing into old age, slows the pace of osteoporosis. The extracellular matrix of bone tissue is constantly remodeled over time, broken down by osteoclasts and built up by osteoblasts. Osteoporosis is caused by a growing imbalance between these two processes that favors destruction over creation. Bones lose mass and become brittle as a result, eventually becoming a serious health issue.

Many mechanisms are proposed to contribute to osteoporosis. <a href="https://www.fightaging.org/archives/2016/08/considering-the-mechanisms-and-tre…

Source https://www.fightaging.org/archives/2021/04/nicotinamide-riboside-supplementation-beginning-in-mid-life-slows-osteoporosis-in-mice/

In today’s open access paper, researchers report that long-term supplementation with nicotinamide riboside in mice, starting from mid-life and continuing into old age, slows the pace of osteoporosis. The extracellular matrix of bone tissue is constantly remodeled over time, broken down by osteoclasts and built up by osteoblasts. Osteoporosis is caused by a growing imbalance between these two processes that favors destruction over creation. Bones lose mass and become brittle as a result, eventually becoming a serious health issue.

Many mechanisms are proposed to contribute to osteoporosis. <a href="https://www.fightaging.org/archives/2016/08/considering-the-mechanisms-and-tre…

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