Every cell contains hundreds of mitochondria, generating chemical energy store molecules to power cellular biochemistry. Mitochondrial function declines with age, with evidence indicating that a disruption of quality control mechanisms such as mitophagy is the proximate cause. Underlying that are age-related changes in the expression of proteins involved in mitochondrial dynamics, the fusion and fission of mitochondria. Is…
Targeting the Mitochondrial Unfolded Protein Response to Improve Mitochondrial Function
Every cell contains hundreds of mitochondria, generating chemical energy store molecules to power cellular biochemistry. Mitochondrial function declines with age, with evidence indicating that a disruption of quality control mechanisms such as mitophagy is the proximate cause. Underlying that are age-related changes in the expression of proteins involved in mitochondrial dynamics, the fusion and fission of mitochondria. Is…