Source https://www.fightaging.org/archives/2022/01/tdp-43-implicated-in-amyotrophic-lateral-sclerosis/
TDP-43 is one of the more recently discovered problem proteins in the aging brain, capable of misfolding and aggregating in ways that promote neurodegeneration and the onset of dementia. This occurs to at least some degree in all older individuals, but where this aggregation is particularly pronounced it can give rise to conditions such as amyotrophic lateral sclerosis. Here, researchers report on their investigations of the biochemistry of this dysfunction, providing further evidence for TDP-43 aggregation to cause the onset and progression of amyotrophic lateral sclerosis.
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Source https://www.fightaging.org/archives/2022/01/tdp-43-implicated-in-amyotrophic-lateral-sclerosis/
TDP-43 is one of the more recently discovered problem proteins in the aging brain, capable of misfolding and aggregating in ways that promote neurodegeneration and the onset of dementia. This occurs to at least some degree in all older individuals, but where this aggregation is particularly pronounced it can give rise to conditions such as amyotrophic lateral sclerosis. Here, researchers report on their investigations of the biochemistry of this dysfunction, providing further evidence for TDP-43 aggregation to cause the onset and progression of amyotrophic lateral sclerosis.
…
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