Source https://www.fightaging.org/archives/2022/01/the-metabolome-as-a-biomarker-of-aging-in-flies/
One of the many approaches to building a clock that can determine biological age is to mine the data of the metabolome, the levels of various small molecule metabolites used and generated by cells. Shifts in the metabolome will reflect age-related changes in function and cell behavior. As is the case for all such clocks, finding a good correlation with mortality and morbidity in the data using machine learning approaches doesn’t provide any insight into why these relationships exist. That makes it challenging to use such a clock to assess potential interventions to slow or reverse aging, as it is by no means clear that a given clock will usefully reflect the outcome of a given intervention targeting o…
Source https://www.fightaging.org/archives/2022/01/the-metabolome-as-a-biomarker-of-aging-in-flies/
One of the many approaches to building a clock that can determine biological age is to mine the data of the metabolome, the levels of various small molecule metabolites used and generated by cells. Shifts in the metabolome will reflect age-related changes in function and cell behavior. As is the case for all such clocks, finding a good correlation with mortality and morbidity in the data using machine learning approaches doesn’t provide any insight into why these relationships exist. That makes it challenging to use such a clock to assess potential interventions to slow or reverse aging, as it is by no means clear that a given clock will usefully reflect the outcome of a given intervention targeting o…
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