Author: Tom

Source https://www.fightaging.org/archives/2021/08/procaine-as-an-example-of-the-slow-reclassification-of-known-small-molecule-drugs-as-geroprotectors/

The classification of “geroprotector” is fairly recent. In present use, it largely means a small molecule drug that can favorably target mechanisms known to be associated with aging. Some of these small molecules come with evidence for a slowing of aging in animal studies. A very few can boast evidence for the same from human trials. Most geroprotectors target stress response mechanisms, those involved in calorie restriction, but senotherapeutic drugs that reduce the burden of cellular senescence might also be classed as geroprotectors.

That a drug can be called geroprotective is no guarantee that it is actually useful, of course. Effect size…

Source https://tinybuddha.com/blog/afraid-of-what-people-think-free-yourself-by-realizing-how-unimportant-you-are/

“You wouldn’t worry so much about what others think of you if you realized how seldom they do.” ~Eleanor Roosevelt

It’s natural to think that we’re always in the spotlight.

We think that people care about the way we dress, but they don’t.

We think that people notice our nervous habits, when in reality, they’re worried about whether people are noticing their own.

We tend to go through life as if our every move is being watched, judged, and evaluated on a moment-to-moment basis by the people around us. Here’s a reality check—you’re not that important.

I don’t mean that in a brash way. This shouldn’t make you feel small or inferior, it should liberate you. And if it doesn’t, I have a feeling that what I’m about to…

Source https://www.fightaging.org/archives/2021/08/poor-diet-and-lack-of-exercise-correlate-with-risk-of-cognitive-decline-and-dementia/

It is not surprising to find data showing that a poor diet and lack of exercise correlated with an increased risk of later neurodegeneration and dementia. Plenty of studies exist to note that correlation. The question is the degree to which it is correlation versus causation. There are good reasons to believe that regular exercise slows the onset of neurodegeneration, quite clear mechanistic links that are demonstrated to be causal in animal studies. Equally, a poor diet and lack of exercise correlate with many other potential contributing factors in human populations, not least of which is frailty and other manifestations of aging. So to what degree do these correlations in human data r…

Source https://seniorplanet.org/get-social-while-travelling-solo/

Don’t let the lack of a travelling companion keep you at home. Here’s the scoop on ways to travel solo and meet new people.

The post Get Social while Travelling Solo appeared first on Senior Planet.

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Source https://greatist.com/fitness/trail-running-shoes

Trail running shoes were designed with diverse terrains in mind. The tricky thing is, there are, like, a ka-billion to choose from. But don’t worry fam, we have your tootsies covered.

Here are the 10 best trail running shoes of 2021.

Source https://www.fightaging.org/archives/2021/08/cell-therapy-improves-tendon-regeneration-in-sheep/

Researchers here move from rodents to sheep in testing the ability of a comparatively simple autologous cell therapy to improve regeneration following tendon injury. The results appear much the same in both species, which suggests that human trials will produce positive results. This approach will join a few other cell therapies aimed at tendon repair and tested in human trials over the past twenty years. The field moves slowly, like much of medicine.

In the search for new and better ways to heal injured tendons, the medical world is looking closely at regenerative therapies. In particular, autologous adipose micrografts (AAMGs) and <a href="https://en.wikipedia.org/wiki…