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SFRP1 as a Target for the Activation of Neural Progenitor Cells

Source https://www.fightaging.org/archives/2022/03/sfrp1-as-a-target-for-the-activation-of-neural-progenitor-cells/

Increased generation of new neurons in the brain, upregulation of the process of neurogenesis, is an important goal for the field of regenerative medicine. It would likely improve brain function at all ages, but since neurogenesis declines with age as stem cell populations become less active, it would be of particular relevance to the aging brain. Thus researchers are looking for ways to influence the regulatory systems controlling quiescence versus activity in neural stem cells and progenitor cells, in order to override the natural response to the aged tissue environment and put them back to work.

In most mammals, …

Source https://www.fightaging.org/archives/2022/03/sfrp1-as-a-target-for-the-activation-of-neural-progenitor-cells/

Increased generation of new neurons in the brain, upregulation of the process of neurogenesis, is an important goal for the field of regenerative medicine. It would likely improve brain function at all ages, but since neurogenesis declines with age as stem cell populations become less active, it would be of particular relevance to the aging brain. Thus researchers are looking for ways to influence the regulatory systems controlling quiescence versus activity in neural stem cells and progenitor cells, in order to override the natural response to the aged tissue environment and put them back to work.

In most mammals, …

Should I Actually Be Working on Cryonics Rather than Rejuvenation?

Source https://www.fightaging.org/archives/2022/03/should-i-actually-be-working-on-cryonics-rather-than-rejuvenation/

The small, long-standing cryonics community and industry is focused on saving lives by offering the possibility of low-temperature storage at death, using cryoprotectants to induce a state of vitrification rather than straight freezing, a shot at preserving the structure and data of the mind for a future society capable of revival from this state. This has been an ongoing project for quite some time now, since the 1960s or so, albeit with a small budget and few research programs.

I was recently in New York to attend the 50th anniversary gathering for the Alcor Life Extension Foundation, among the oldest of cryonics organizations. It was an occasion also marking the launch of a new book by <a href=…

Source https://www.fightaging.org/archives/2022/03/should-i-actually-be-working-on-cryonics-rather-than-rejuvenation/

The small, long-standing cryonics community and industry is focused on saving lives by offering the possibility of low-temperature storage at death, using cryoprotectants to induce a state of vitrification rather than straight freezing, a shot at preserving the structure and data of the mind for a future society capable of revival from this state. This has been an ongoing project for quite some time now, since the 1960s or so, albeit with a small budget and few research programs.

I was recently in New York to attend the 50th anniversary gathering for the Alcor Life Extension Foundation, among the oldest of cryonics organizations. It was an occasion also marking the launch of a new book by <a href=…

CYTOR Upregulation Increases Muscle Function in Aged Mice

Source https://www.fightaging.org/archives/2022/03/cytor-upregulation-increases-muscle-function-in-aged-mice/

Researchers have in recent years identified CYTOR as a regulator of muscle growth, a line of work that is progressing towards the development of therapies to combat sarcopenia, the age-related loss of muscle mass and strength. This is a compensatory approach, forcing cells to override their natural response to the aged environment rather than trying to address the environment itself. Since evidence suggests that aged muscle stem cells are competent, capable of function, but made quiescent in response to the altered signaling environment in old tissues, restoring stem cell function (and thus muscle maintenance and growth) in this way may be at the more effective end of what is possible to achieve in the treatment of aging without targeting the deep…

Source https://www.fightaging.org/archives/2022/03/cytor-upregulation-increases-muscle-function-in-aged-mice/

Researchers have in recent years identified CYTOR as a regulator of muscle growth, a line of work that is progressing towards the development of therapies to combat sarcopenia, the age-related loss of muscle mass and strength. This is a compensatory approach, forcing cells to override their natural response to the aged environment rather than trying to address the environment itself. Since evidence suggests that aged muscle stem cells are competent, capable of function, but made quiescent in response to the altered signaling environment in old tissues, restoring stem cell function (and thus muscle maintenance and growth) in this way may be at the more effective end of what is possible to achieve in the treatment of aging without targeting the deep…

The Human Evidence for Transcranial Direct Current Stimulation as a Treatment for Neurodegeneration

Source https://www.fightaging.org/archives/2022/03/the-human-evidence-for-transcranial-direct-current-stimulation-as-a-treatment-for-neurodegeneration/

One of the impressions received from the literature on electromagnetic stimulation of the brain is that results likely depend strongly on the fine details of the protocol. Current, frequency, duration, and any of the score of other parameters that can be adjusted via a different experimental setup. The use of direct current may have better results to date simply because there are fewer parameters to adjust. Nonetheless, “better results to date” is not a glowing recommendation. The bar as very low, and as pointed out here, the state of clinical trials seen as a whole isn’t all that convincing. You might compare this with a <a href="https://www.fightaging.org/archives/2021/07/reviewing-…

Source https://www.fightaging.org/archives/2022/03/the-human-evidence-for-transcranial-direct-current-stimulation-as-a-treatment-for-neurodegeneration/

One of the impressions received from the literature on electromagnetic stimulation of the brain is that results likely depend strongly on the fine details of the protocol. Current, frequency, duration, and any of the score of other parameters that can be adjusted via a different experimental setup. The use of direct current may have better results to date simply because there are fewer parameters to adjust. Nonetheless, “better results to date” is not a glowing recommendation. The bar as very low, and as pointed out here, the state of clinical trials seen as a whole isn’t all that convincing. You might compare this with a <a href="https://www.fightaging.org/archives/2021/07/reviewing-…

Client remote monitoring for home care agencies — why and what?

Source https://www.ageinplacetech.com/blog/client-remote-monitoring-home-care-agencies-why-and-what

Why should home care agencies boost awareness of remote monitoring? Both types of monitoring are increasingly likely to be found by home care professionals entering a new care recipient’s home.  The objective of these remote monitoring technologies is to help healthcare teams, care workers and/or families understand if any issues are occurring inside the home when they cannot be there in person.  Patients with chronic diseases or those who are discharged from hospitals may benefit from the use of RPM technology to monitor significant chronic disease…

Source https://www.ageinplacetech.com/blog/client-remote-monitoring-home-care-agencies-why-and-what

Why should home care agencies boost awareness of remote monitoring? Both types of monitoring are increasingly likely to be found by home care professionals entering a new care recipient’s home.  The objective of these remote monitoring technologies is to help healthcare teams, care workers and/or families understand if any issues are occurring inside the home when they cannot be there in person.  Patients with chronic diseases or those who are discharged from hospitals may benefit from the use of RPM technology to monitor significant chronic disease…

Senior Planet Book Club: Vote For Our Next Book!

Source https://seniorplanet.org/senior-planet-book-club-vote-for-our-next-book-17/

Which book should we read next?

The post Senior Planet Book Club: Vote For Our Next Book! appeared first on Senior Planet.

Source https://seniorplanet.org/senior-planet-book-club-vote-for-our-next-book-17/

Which book should we read next?

The post Senior Planet Book Club: Vote For Our Next Book! appeared first on Senior Planet.

Senior Planet talks to…Wallace Shawn

Source https://seniorplanet.org/senior-planet-talks-to-wallace-shawn/

Wallace Shawn tells Senior Planet how he’s been spending the pandemic….but does he reveal his favorite role?

The post Senior Planet talks to…Wallace Shawn appeared first on Senior Planet.

Source https://seniorplanet.org/senior-planet-talks-to-wallace-shawn/

Wallace Shawn tells Senior Planet how he’s been spending the pandemic….but does he reveal his favorite role?

The post Senior Planet talks to…Wallace Shawn appeared first on Senior Planet.

Arguing for a Rate of Living View of Aging

Source https://www.fightaging.org/archives/2022/03/arguing-for-a-rate-of-living-view-of-aging/

The rate of living view of aging is one of the discarded historical hypotheses that occurred along the way to the modern competing ideas about why aging occurs, and why there are differences in longevity between species. Roughly, the rate of living hypothesis says that a faster metabolism means a shorter life, that underlying processes (such as accumulation of molecular damage) depend strongly on metabolic rate. This doesn’t appear to be the case, however; setting aside more detailed considerations, there are enough exceptions to the rule, species with high metabolism and exceptional longevity, to sink the argument. It isn’t just metabolic rate that determines species longevity.

In today’s single author paper, rate of living…

Source https://www.fightaging.org/archives/2022/03/arguing-for-a-rate-of-living-view-of-aging/

The rate of living view of aging is one of the discarded historical hypotheses that occurred along the way to the modern competing ideas about why aging occurs, and why there are differences in longevity between species. Roughly, the rate of living hypothesis says that a faster metabolism means a shorter life, that underlying processes (such as accumulation of molecular damage) depend strongly on metabolic rate. This doesn’t appear to be the case, however; setting aside more detailed considerations, there are enough exceptions to the rule, species with high metabolism and exceptional longevity, to sink the argument. It isn’t just metabolic rate that determines species longevity.

In today’s single author paper, rate of living…

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