This article on senolytic therapies to selectively remove senescent cells in old tissues is in part a matter of Unity Biotechnology talking up their position. The company suffered from first mover disadvantage in bringing senolytic drugs into clinical development. The field has made progress very rapidly over the last decade, and startups founded even just a couple of years after Unity’s launch benefited from greater knowledge and a selection of better technologies to work with. Still, one can be talking up one’s position and also be right. The accumulation of senescent cells is profoundly harmful, a significant contribution to degenerative aging, and senolytics are indeed a promising approach to…
This article on senolytic therapies to selectively remove senescent cells in old tissues is in part a matter of Unity Biotechnology talking up their position. The company suffered from first mover disadvantage in bringing senolytic drugs into clinical development. The field has made progress very rapidly over the last decade, and startups founded even just a couple of years after Unity’s launch benefited from greater knowledge and a selection of better technologies to work with. Still, one can be talking up one’s position and also be right. The accumulation of senescent cells is profoundly harmful, a significant contribution to degenerative aging, and senolytics are indeed a promising approach to…
Reprogramming cells using the Yamanaka factors produces both a reset of epigenetic patterns to a more youthful configuration and a change in cell identify. One of the primary challenges inherent in reprogramming to achieve rejuvenation is avoidance of this altered cell identity. Reprogramming isn’t an immediate switch, it is a slow process over hours to days, but a fraction of reprogrammed cells do change into induced pluripotent stem cells after some period of exposure to reprogramming factors. This is an undesirable outcome when delivering a reprogramming therapy; if new approaches can be found that do not alter cell identity, that would make reprogramming a much more viable basis for rejuvenation treatments.
Reprogramming cells using the Yamanaka factors produces both a reset of epigenetic patterns to a more youthful configuration and a change in cell identify. One of the primary challenges inherent in reprogramming to achieve rejuvenation is avoidance of this altered cell identity. Reprogramming isn’t an immediate switch, it is a slow process over hours to days, but a fraction of reprogrammed cells do change into induced pluripotent stem cells after some period of exposure to reprogramming factors. This is an undesirable outcome when delivering a reprogramming therapy; if new approaches can be found that do not alter cell identity, that would make reprogramming a much more viable basis for rejuvenation treatments.
Monocytes of the innate immune system react to changes in the aging tissue environment by becoming more inflammatory. Those changes include the signaling of growing numbers of senescent cells, the presence of DNA debris from stressed cells, and the like. The innate immune system makes the issue worse by ensuring a state of chronic inflammation that disrupts normal tissue maintenance and function. Finding ways to suppress the inflammation of aging, such as the <a href="https://www.fightaging.org/archives/2017/09/senolytic-therapies-to-clear-senescent-cells-will-transform-t…
Monocytes of the innate immune system react to changes in the aging tissue environment by becoming more inflammatory. Those changes include the signaling of growing numbers of senescent cells, the presence of DNA debris from stressed cells, and the like. The innate immune system makes the issue worse by ensuring a state of chronic inflammation that disrupts normal tissue maintenance and function. Finding ways to suppress the inflammation of aging, such as the <a href="https://www.fightaging.org/archives/2017/09/senolytic-therapies-to-clear-senescent-cells-will-transform-t…
The balance of microbial populations making up the gut microbiome is now known to change with age in ways that promote chronic inflammation. There are more inflammatory microbes passing the intestinal barrier to enter tissue, and more microbes capable of generating harmful metabolites that aggravate cells. The aging of the microbiome is only loosely connected to the aging of the body, however. Animal studies make it clear that the gut microbiome of an old individual can be restored to a youthful balance of p…
The balance of microbial populations making up the gut microbiome is now known to change with age in ways that promote chronic inflammation. There are more inflammatory microbes passing the intestinal barrier to enter tissue, and more microbes capable of generating harmful metabolites that aggravate cells. The aging of the microbiome is only loosely connected to the aging of the body, however. Animal studies make it clear that the gut microbiome of an old individual can be restored to a youthful balance of p…
It’s a story that my wife was very hesitant for me to share publicly.
But it’s a scary wake-up call that we need to share as people who care deeply about the plant-based movement and getting people healthy with whole-foods nutrition.
Because if it can happen to me (someone who thinks about plant-based nutrition, literally, every single day) then it can happen to anyone. Here’s the story:
We recently (secretly) launched a new platform for checking your micronutrients and other biomarkers using a third-party, CLIA-certified lab. It’s pretty cool.
So obviously I wanted my wife to benefit from that peace of mind, especially because she’s nursing our new baby.
In particular, I was concerned about her levels of Vitamin D and DHA, which are absolutely critical for a growing child. And up until starting solid foods, the baby’s only source of nutrition is mom’s nutrients.
It’s a story that my wife was very hesitant for me to share publicly.
But it’s a scary wake-up call that we need to share as people who care deeply about the plant-based movement and getting people healthy with whole-foods nutrition.
Because if it can happen to me (someone who thinks about plant-based nutrition, literally, every single day) then it can happen to anyone. Here’s the story:
We recently (secretly) launched a new platform for checking your micronutrients and other biomarkers using a third-party, CLIA-certified lab. It’s pretty cool.
So obviously I wanted my wife to benefit from that peace of mind, especially because she’s nursing our new baby.
In particular, I was concerned about her levels of Vitamin D and DHA, which are absolutely critical for a growing child. And up until starting solid foods, the baby’s only source of nutrition is mom’s nutrients.
Old-school weightlifting offers a wide range of benefits for the body. It’s a great way to build bulk, increase strength, and improve tone.
Whether you want to get swole — or just want to tone and strengthen — old school bodybuilding can help you hit your goals. Here’s a rundown of the best vintage workouts for all fitness levels.
Old-school weightlifting offers a wide range of benefits for the body. It’s a great way to build bulk, increase strength, and improve tone.
Whether you want to get swole — or just want to tone and strengthen — old school bodybuilding can help you hit your goals. Here’s a rundown of the best vintage workouts for all fitness levels.
The Valsalva Maneuver is a breathing method that involves holding air in your lungs by closing the glottis. It can be an effective tool in weight lifting routines.
Breath exercises can be a game changer. They can help you sleep, make you relax, and benefit your overall mental and physical health. But did you know breathing can also help you get swoll? Well, not exactly. But a breathing exercise known as Valsalva maneuver breathing might enhance your weight lifting regime.
Here’s a rundown of the pros and cons of Valsalva Maneuver for strength training. We also have a step-by-step guide on how to do it during your next lift sesh.
The Valsalva Maneuver is a breathing method that involves holding air in your lungs by closing the glottis. It can be an effective tool in weight lifting routines.
Breath exercises can be a game changer. They can help you sleep, make you relax, and benefit your overall mental and physical health. But did you know breathing can also help you get swoll? Well, not exactly. But a breathing exercise known as Valsalva maneuver breathing might enhance your weight lifting regime.
Here’s a rundown of the pros and cons of Valsalva Maneuver for strength training. We also have a step-by-step guide on how to do it during your next lift sesh.
Perfectly tender and subtly spiced pears in just 8 minutes? Yes, please! These caramelized sautéed pears are a warming, versatile addition to porridge (recipe coming soon), oatmeal, waffles, pancakes, yogurt, ice cream, and more.
Made with just 5 simple ingredients in 1 pan, they’re the perfect quick and classy treat. Let us show you how it’s done!
Perfectly tender and subtly spiced pears in just 8 minutes? Yes, please! These caramelized sautéed pears are a warming, versatile addition to porridge (recipe coming soon), oatmeal, waffles, pancakes, yogurt, ice cream, and more.
Made with just 5 simple ingredients in 1 pan, they’re the perfect quick and classy treat. Let us show you how it’s done!
